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3D QASR, Antimicrobial Activity and Molecular Docking Studies of C-14 Chiral Matrine Derivatives as Potential Antibiotics.
Chem Biodivers
January 2025
Guangxi University, School of Medicine, Xixiangtang district, 530004, Nanning, CHINA.
Antibiotic resistance is recognized as one of the top ten global public health threats, posing a significant challenge to human health. The stereochemistry of chiral molecules, alongside their specific interactions with biological targets, provides essential insights for the development of novel antibacterial agents, This study investigated the antibacterial activity of 32 previously synthesized 14-position chiral matrine derivatives. Among these derivatives, compound Q4 exhibited the strongest activity against Propionibacterium acnes, with a minimum inhibitory concentration (MIC) of 0.
View Article and Find Full Text PDFDevelopment of nanofiber facial mask inspired by the multi-function of dried ginger (Zingiberis Rhizoma) essential oil.
Sci Rep
January 2025
School of Pharmacy, School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Plant extracts, especially herbal extracts, are in line with the cosmetics development trend of natural and safe in today's world. Dried ginger essential oil (DGEO) is a fragrant oily liquid extracted from the dried roots of Zingiber officinale Rosc. This research investigated DGEO could effectively inhibit Staphylococcus aureus and Propionibacterium acnes.
View Article and Find Full Text PDFThe combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway.
Eur J Pharmacol
December 2024
Department of Anatomy and Histology & Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, 650500, China. Electronic address:
Acne is a prevalent and chronic inflammatory skin disease, and its treatment remains a huge clinical challenge. In the present study, we evaluated the therapeutic potential of combining the peptides RL-QN15 and OH-CATH30 for the treatment of acne in mice. Results indicated that the topical application of RL-QN15 and OH-CATH30 significantly inhibited the proliferation of Propionibacterium acnes (P.
View Article and Find Full Text PDFAnti-microbial impact of non-antibiotic agents; salicylic acid, N-acetylcysteine, and isotretinoin against Cutibacterium acnes in patients with acne vulgaris.
Arch Dermatol Res
December 2024
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
There are two main strategies to eliminate Cutibacterium acnes and to reduce antibiotic resistance in acne treatment. The first is to target the pathogenic bacteria and the second is to change the environment for their growth. The present study aimed to evaluate the anti-microbial role of non-antibiotic agents against Cutibacterium acnes (C.
View Article and Find Full Text PDFStaphylococcus caprae and Staphylococcus epidermidis define the skin microbiome among different grades of acne vulgaris.
Arch Dermatol Res
December 2024
Faculty of Medicine, Department of Dermatology and Venereology, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Acne vulgaris (AV) has been associated with Cutibacterium acnes (C. acnes) colonization in sebaceous follicles. However, recent studies have revealed the role of skin microbiome dysbiosis in acne pathogenesis.
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