The use of the time-multiplexing super-resolution method for extending the depth of focus of an imaging system was recently presented [Opt. Lett.41, 183 (2016)OPLEDP0146-959210.1364/OL.41.000183]. It involved changing the encoding and decoding gratings frequencies, which determine the optical transfer function duplications positions, and by that obtaining an extended depth of focus. In this Letter we expand this method by showing its applicability for correcting geometrical aberrations of an imaging lens. The proposed method is presented analytically, and validated experimentally for chromatic aberration, spherical aberration, and astigmatism aberration.

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.41.004257DOI Listing

Publication Analysis

Top Keywords

geometrical aberrations
8
depth focus
8
time multiplexing
4
multiplexing based
4
based geometrical
4
aberrations correction
4
correction time-multiplexing
4
time-multiplexing super-resolution
4
super-resolution method
4
method extending
4

Similar Publications

Conventional refractive microscope objective lenses have limited applicability to a range of imaging modalities due to the dispersive nature of their optical elements. Designing a conventional refractive microscope objective that provides well-corrected imaging over a broad spectral range can be challenging, if not impossible. In contrast, reflective optics are inherently achromatic, so a system composed entirely of reflective elements is free from chromatic aberrations and, as a result, can image over an ultra-wide spectral range with perfect color correction.

View Article and Find Full Text PDF

The aberrant aggregation of the human islet amyloid polypeptide (hIAPP) is a hallmark of type II diabetes. LL37, the only cathelicidin host-defense peptide in humans, plays essential roles in antimicrobial and immunomodulatory activities. Mounting evidence indicates that LL37 can inhibit the amyloid aggregation of hIAPP, suggesting possible interplays between infections and amyloid diseases while the mechanism remains unclear.

View Article and Find Full Text PDF

Human lens epithelial cells (hLECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to hLECs, especially to sub-cellular organelles (e.g.

View Article and Find Full Text PDF

Fascin structural plasticity mediates flexible actin bundle construction.

Nat Struct Mol Biol

January 2025

Laboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.

Fascin cross-links actin filaments (F-actin) into bundles that support tubular membrane protrusions including filopodia and stereocilia. Fascin dysregulation drives aberrant cell migration during metastasis, and fascin inhibitors are under development as cancer therapeutics. Here, we use cryo-EM, cryo-electron tomography coupled with custom denoising and computational modeling to probe human fascin-1's F-actin cross-linking mechanisms across spatial scales.

View Article and Find Full Text PDF

Gold nanocube-enhanced SERS biosensor based on heated electrode coupled with exonuclease III-assisted cycle amplification for sensitive detection of flap endonuclease 1 activity.

Talanta

December 2024

Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, China. Electronic address:

The flap endonuclease 1 (FEN1) plays a key role in DNA replication and repair, its aberrant expression is associated with tumor development, so it has been recognized as a promising biomarker for a variety of cancers. Here, a novel "turn on" mode gold nanocube-enhanced surface-enhanced Raman scattering (SERS) biosensor was constructed by combining a heated Au electrode (HAuE), exonuclease III (Exo III)-assisted cycle amplification, and gold nanocube (AuNC)-based SERS enhancement to achieve highly sensitive detection of FEN1 activity. The SERS tag was prepared using the Raman reporter modified on the AuNC surface, and the high electromagnetic field provided by the sharp geometric feature of AuNC greatly enhanced the SERS signal.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!