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Atrial Fibrillation and Retinal Stroke.
JAMA Netw Open
January 2025
Department of Neurology, Duke University School of Medicine, Durham, North Carolina.
Importance: Atrial fibrillation (AF) is the most common, chronic, cardiac arrythmia in older US adults. It is not known whether AF is independently associated with increased risk of retinal stroke (central retinal artery occlusion), a subtype of ischemic stroke that causes severely disabling visual loss in most cases and is a harbinger of further vascular events.
Objective: To determine whether there is an association between AF and retinal stroke.
Developing Topics.
Alzheimers Dement
December 2024
University College London, London, United Kingdom.
Background: Studies that report an association between anticholinergic medications and dementia often suffer from confounding by indication and rarely consider gender effects. We estimated the association between recurrent prescriptions for anticholinergic overactive bladder (OAB) medications and incident dementia, separately in men and women.
Method: We studied patients aged ≥50 years first prescribed an anticholinergic OAB drug (e.
Developing Topics.
Alzheimers Dement
December 2024
London School of Hygiene and Tropical Medicine, London, United Kingdom.
Background: Some infections may be associated with poor brain health, but evidence from low and middle-income countries (LMICs) is limited. Therefore, we aimed to investigate associations between nine infections and cognitive function, depression, and frailty in India.
Methods: We conducted a cross-sectional study using data from Wave 1 (2017-2019) of the Longitudinal Aging Study in India (LASI) survey of adults (≥45years) from 35 of India's 36 states and union territories.
Developing Topics.
Alzheimers Dement
December 2024
State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, Shanghai, China.
Background: Dementia patients often have several co-existing diseases, whereas the specific temporality and development patterns between them remain uncertain.
Method: Based on the multicenter, community-based prospective UK Biobank, enriched disease diagnoses were extracted from hospital admission linkage, along with basic demographic information and individual genome data from the baseline visit. We constructed disease trajectory before dementia utilizing the phenome-wide association analysis to firstly filter potential precursors, the directional test to select temporal disease pairs, and conditional logistic regression to finally quantify association strength.
Dementia Care Practice.
Alzheimers Dement
December 2024
Noesis Cognitive Center & Tech Solutions Ltd, Nicosia, Cyprus.
Background: A 69-year-old retired businessman, born in 1954, with 12 years of education, had been participating in cognitive enhancement sessions for the past 5 years. His medical history included two ischemic strokes, left hemiplegia, as well as disturbances in the left visual field. This study aimed to examine the individual's cognitive performance over the course of these 5 years, including the COVID-19 pandemic period.
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