AI Article Synopsis
- PET scans can be important for studying diseases like depression, Alzheimer's, and schizophrenia through the 5-HT receptor system.
- The researchers created a F-labeled version of an earlier C-labeled PET ligand called Cimbi-36, resulting in 5 new ligands.
- However, tests showed that these new ligands didn't effectively block the 5-HT receptors in the brain, making them less useful for imaging in living subjects.
Article Abstract
Positron emission tomography (PET) investigations of the 5-HT receptor (5-HTR) system can be used as a research tool in diseases such as depression, Alzheimer's disease and schizophrenia. We have previously developed a C-labeled agonist PET ligand ([C]Cimbi-36), and the aim of this study was to identify a F-labeled analogue of this PET-ligand. Thus, we developed a convergent radiochemical approach giving easy access to 5 different F-labeled ligands structurally related to Cimbi-36 from a common F-labeled intermediate. After intravenous injection, all ligands entered the pig brain. However, since within-scan intervention with ketanserin, a known orthosteric 5-HT receptor antagonist, did not result in significant blocking, the radioligands seem unsuitable for neuroimaging of the 5-HTR in vivo.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2016.08.056 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!