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Emergence of plasmid-mediated fosfomycin resistance among harboring , (X4), and genes in wild birds.
mSystems
March 2025
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Unlabelled: Fosfomycin represents a last-line reserve antibiotic for the treatment of infections caused by multidrug-resistant (MDR) bacteria. Nevertheless, the advent of plasmid-mediated fosfomycin resistance among bacteria from humans and food animals incurs great concern. This study reports the detection and genomic portrait of the plasmid-mediated fosfomycin resistance gene, , amid from wild birds co-harboring plasmid-mediated tigecycline resistance gene(X4), and colistin resistance gene, .
View Article and Find Full Text PDFDiscovery of triazole derivatives for biofilm disruption, anti-inflammation and metal ion chelation.
Front Chem
February 2025
Department of Pediatrics, Maternity and Child Health Hospital of Qinhuangdao, Qinhuangdao, China.
In the face of bacterial hazards to human health and resistance to multiple antibiotics, there is an urgent need to develop new antibiotics to meet the challenge. In this paper, the triazolyl heterocyclic (3-amino-1,2,4-triazole, ) was synthesised efficiently using thiourea as starting material. Finally, the end product was obtained by aldehyde-amine condensation reaction and the structures of all compounds were determined by spectral analysis.
View Article and Find Full Text PDFMachine Learning-Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent.
Chem Biol Drug Des
March 2025
School of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, China.
The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. Therefore, it is an important target for antibacterial drug research.
View Article and Find Full Text PDFLavandula dentata leaves as potential natural antibiofilm agents against Pseudomonas aeruginosa.
Sci Rep
March 2025
Faculty of Pharmacy, Department of Pharmacognosy, Ain Shams University, Abbassia, 11566, Cairo, Egypt.
Biofilm formation is responsible for persistent diseases related to chronic infections. Mostly it is triggered by many bacteria, mainly Pseudomonas aeruginosa (P. aeruginosa).
View Article and Find Full Text PDFSynergistic photothermal-sonodynamic therapy for antibacterial and immune reprogramming in chronic osteomyelitis.
J Control Release
March 2025
Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address:
The development of antibiotic resistance and inadequate immune response in chronic inflammation pose significant challenges in treating chronic osteomyelitis. As accepted non-antibiotic antimicrobial therapies, sonodynamic therapy (SDT) and photothermal therapy (PTT) are recognized for their effectiveness in eliminating bacteria and promoting tissue repair, rendering them promising therapeutic strategies for treating bacterial infections and preventing the emergence of drug-resistant bacteria. However, the antimicrobial action and efficacy in promoting tissue repair depend on the activation status of the host immune system.
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