AI Article Synopsis

  • Sinusoidal obstructive syndrome (SOS), also known as veno-occlusive disease, is a rare but serious complication that can occur after hematopoietic stem cell transplantation and living donor liver transplantation (LDLT).
  • A case study highlighted a 34-year-old woman who developed SOS after LDLT, believed to be linked to a liver abscess and narrowing of the inferior vena cava.
  • SOS resulted in graft failure, necessitating a retransplant with a liver from a deceased donor, illustrating the complex causes of SOS, which involve issues like reduced blood flow from liver infections and vascular problems.

Article Abstract

The sinusoidal obstructive syndrome (SOS) is a complication that usually follows hematopoietic stem cell transplantation. It is also known as veno-occlusive disease, which is a rare complication of living donor liver transplantation (LDLT). Herein, we reported a 34 year-old female patient presenting SOS after LDLT. Its underlying cause was presumed to be associated with liver abscess and subsequent inferior vena cava stenosis. SOS led to graft failure, thus requiring retransplantation with a deceased donor liver graft. The underlying causes of SOS are complex pathologic entity with multifactorial etiology. It is likely that its multifactorial etiology includes a decrease of hepatic venous outflow that is caused by graft liver infection and inferior vena cava stenosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018956PMC
http://dx.doi.org/10.14701/kjhbps.2016.20.3.133DOI Listing

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