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Photochemically-assisted synthesis of non-toxic and biocompatible gold nanoparticles. | LitMetric

Photochemically-assisted synthesis of non-toxic and biocompatible gold nanoparticles.

Colloids Surf B Biointerfaces

Laboratório de Pesquisa em Polímeros e Nanomateriais, Instituto de Química, Universidade de Brasília, Brasília, DF 70904-970, Brazil. Electronic address:

Published: December 2016

AI Article Synopsis

  • This study outlines a method for creating safe, biocompatible gold nanoparticles (Au-np-PEI) using light, specifically UV irradiation, to transform chloroauric acid into nanoparticles while being stabilized by a polymer called branched polyethylenimine (PEI).
  • The process involves a 30-minute exposure to UV light at room temperature, which allows for precise control over the size of the nanoparticles (ranging from 100nm to 8nm) by adjusting the ratio of PEI to gold.
  • The resulting gold nanoparticles have strong light absorption properties and show high cell viability in tests with human tissues, making this method advantageous due to its speed and absence of toxic

Article Abstract

This contribution describes the photochemically-assisted synthesis of aqueous colloidal suspensions of non-toxic and biocompatible spherical gold nanoparticles stabilized by branched polyethylenimine, or else Au-np-PEI. The method consists on 30min of photoexcitation (254nm, 16W) at room temperature of an aqueous diluted solution of chloroauric acid (HAuCl) containing PEI. While the UV irradiation forms the [AuCl]* excited species that succesively transforms into zero valent Au, PEI controls the nucleation step of nanoparticles formation. Varying the PEI to Au molar ratio permits one to tune the size of nanoparticles between 100nm to 8nm. The obtained colloidal suspensions display an intense plasmonic absorption band at 520-530nm and positive zeta potentials greater than +20mV. The cells viability for in vitro tests performed with human connective tissues and human breast adenocarcinoma (MCF-7) cell lines is over 80% and 90%, respectively, when they are incubated with Au-np-PEI formulations (25μgmL). The present photochemically-assisted synthesis is advantageous because it is fast and does not require for either hazardous or cytotoxic reductant agents and additional purification procedures.

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Source
http://dx.doi.org/10.1016/j.colsurfb.2016.09.002DOI Listing

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