AI Article Synopsis
- Psychiatric disorders are major public health concerns due to their disabling nature, often linked to neuroanatomical or biochemical changes from inadequate neurodevelopment.
- Recent studies highlight specific growth factors, like BDNF and EGF, as influential in the development and progression of disorders such as schizophrenia, depression, bipolar disorder, and anxiety.
- These growth factors may serve as potential biological markers for diagnosing and predicting outcomes related to cognitive, emotional, and social impairments in various psychiatric conditions.
Article Abstract
The psychiatric disorders are one of the most disabling illnesses in the world and represent a major problem for public health. These disorders are characterized by neuroanatomical or biochemical changes and it has been suggested that such changes may be due to inadequate neurodevelopment. Diverse alterations in the gene expression and/or serum level of specific growth factors have been implicated in the etiology, symptoms and progression of some psychiatric disorders. Herein, we summarize the latest information regarding the role of brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), fibroblast growth factor (FGF), Insulin-like growth factor (IGF-1), neuroregulin-1 (NGR-1), erythropoietin (EPO), vascular growth factor (VEGF), transforming growth factor beta (TGF-β), nerve growth factor (NGF) and others cytokines in the pathogenesis of schizophrenia, depression, bipolar and anxiety disorders. Focusing on the role of these growth factors and their relationship with the main impairments (cognitive, emotional and social) of these pathologies. Some of these signaling molecules may be suitable biological markers for diagnosis and prognosis in cognitive, mood and social disabilities across different mental disorders.
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| http://dx.doi.org/10.1016/j.cytogfr.2016.08.004 | DOI Listing |
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