Background: Deep brain stimulation is an effective treatment for movement disorders, but it is relatively complex, invasive, and costly. Little is known about whether stimulation mode alters pulse generator (battery) longevity in routine clinical care.
Objective: To compare battery longevity during monopolar versus bipolar stimulation in patients who underwent deep brain stimulation for movement disorders.
Methods: We evaluated 2,902 programming adjustments and calculated the average stimulator settings for 393 batteries in 200 unique patients with Parkinson's disease and essential tremor. We classified the pulse generators into different stimulation modes (monopolar, bipolar, tripolar, double monopolar) and compared battery longevity with Kaplan Meier survival analyses using the log rank test. We exclusively implanted the Medtronic 3387 lead with adjacent electrode contacts separated by 1.5 mm.
Results: The mean pulse generator longevity was 47.6±1.6 months regardless of diagnosis or stimulation mode. Bipolar stimulation mode was associated with greater longevity than monopolar stimulation (56.1±3.4 versus 44.2±2.1 months, p=0.006). This effect was most pronounced when stimulation parameters were at low to moderate intensity settings. Double monopolar configuration was associated with less pulse generator longevity than conventional stimulation modes (37.8±5.6 versus 49.7±1.9, p=0.014).
Conclusion: IPGs initially programmed in bipolar mode provided one year of additional battery longevity versus monopolar mode in this large retrospective series of patients with essential tremor and Parkinson's disease. Given satisfactory efficacy for motor symptoms, bipolar stimulation mode is a feasible alternative programming strategy at the initiation of DBS therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015697 | PMC |
| http://dx.doi.org/10.1002/mdc3.12285 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing battery longevity by regulating the solvation chemistry of organic iodide.
Angew Chem Int Ed Engl
December 2024
Key Laboratory for Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
For rechargeable zinc-iodine batteries, the low electrical conductivity of iodine and the easy dissolution of polyiodide in the electrolyte need to be carefully managed to ensure efficient operation. Herein, we introduce an organic iodized salt, formamidinium iodide (CHNI), to modulate the solvation structure of iodide ion, aimed to improve the reaction kinetics of iodine for reversible redox conversion. The participation of formamidinium ion (FA) into solvation structure leads to the formation of the favorable FAIZn(HO) complex, facilitating easier desolvation for redox conversion with iodine.
View Article and Find Full Text PDFUnlocking Sulfide Solid-State Battery Longevity by the Paradigm of Dual-Functional Plastic Crystal.
ACS Nano
January 2025
Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, Fudan University, Shanghai 200438, China.
The utilization of sulfide-based solid electrolytes represents an attractive avenue for high safety and energy density all-solid-state batteries. However, the potential has been impeded by electrochemical and mechanical stability at the interface of oxide cathodes. Plastic crystals, a class of organic materials exhibiting remarkable elasticity, chemical stability, and ionic conductivity, have previously been underutilized due to their susceptibility to dissolution in liquid electrolytes.
View Article and Find Full Text PDFRecollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults.
Neurobiol Aging
December 2024
Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA.
The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data were acquired between the first two sessions and included an in-scanner associative recognition procedure enabling estimation of MTL encoding and recollection fMRI BOLD effects.
View Article and Find Full Text PDFCost-effectiveness analysis of deep brain stimulation versus treatment as usual for treatment-resistant obsessive-compulsive disorder.
J Neurosurg
January 2025
1Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Objective: Deep brain stimulation (DBS) is an effective neurosurgical option for patients with treatment-resistant obsessive-compulsive disorder (OCD). Despite being more costly than neuroablative procedures of comparable efficacy, DBS has gained popularity over the years for its reversibility and adjustability. Although the cost-effectiveness of DBS has been investigated extensively in movement disorders, few economic analyses of DBS for psychiatric disorders exist.
View Article and Find Full Text PDFAdvancement in piezoelectric nanogenerators for acoustic energy harvesting.
Microsyst Nanoeng
December 2024
Department of Computer and Information Engineering, Khalifa University, Abu Dhabi, 12778, UAE.
The demand for sustainable energy sources to power small electronics like IoT devices has led to exploring innovative solutions like acoustic energy harvesting using piezoelectric nanogenerators (PENGs). Acoustic energy harvesting leverages ambient noise, converting it into electrical energy through the piezoelectric effect, where certain materials generate an electric charge in response to mechanical stress or vibrations. This review paper provides a comprehensive analysis of the advancements in PENG technology, emphasizing their role in acoustic energy harvesting.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!