AI Article Synopsis
- A new reaction has been developed that uses gold as a catalyst to combine ynamides with 3-substituted indoles, which act as nucleophiles.
- This process results in the production of a novel type of compounds known as 2-vinylindole derivatives.
- The reaction proceeds efficiently through an intermediate called a cyclopropyl gold-carbenoid species, leading to good yields.
Article Abstract
A new gold-catalyzed reaction of ynamides with 3-substituted indoles as nucleophiles is reported. The reaction allows for the synthesis of a new class of 2-vinylindole derivatives in good yields via the intermediacy of a cyclopropyl gold-carbenoid species.
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| http://dx.doi.org/10.1021/acs.orglett.6b02189 | DOI Listing |
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