Parkinson's disease is one of the most common neurodegenerative disorders. There are many documents about the effects of oxidative stress in Parkinson's disease etiology. Angiotensin II activates NADPH dependent oxidases and causes superoxides formation. Peganum harmala L. extract, which has angiotensin converting enzyme (ACE) inhibitory effect, is considered to evaluate oxidative stress inhibition and Parkinson's disease improvement. Male rats weighting 200-250 g were divided into 5 groups: Control, Neurotoxin (injection of 6-hydroxydopamine into left hemisphere substantia nigra), Peganum harmala's seeds aqueous extract (10 mg/kg) and captopril (5 mg/kg). Peganum harmala and captopril were injected intraperitonealy -144, -120, -96, -72, -48, -24, -2, 4 and 24 h relative to 6-hydroxydopamine injection time. Muscle stiffness, apomorphine induced unilateral rotation, amount of brain's protein oxidation and lipid peroxidation, ACE activity and histology of substantia nigra were assayed in all groups. Peganum harmala improved Muscle stiffness and one-direction rotation behavior significantly. It also reduced brain's lipid and protein oxidation levels in neurotoxin-injected rats significantly. In Peganum harmala group compared to control group, brain's ACE activity was significantly inhibited. In histological study, Peganum harmala prevented degeneration of dopaminergic neurons, too. In conclusion, aqueous extract of Peganum harmala could prevent symptoms and reduced oxidative stress markers in rats with Parkinson's disease induced by 6-hydroxydopamine.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986102 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Resource distribution, pharmacological activity, toxicology and clinical drugs of β-Carboline alkaloids: An updated and systematic review.
Fitoterapia
December 2024
School of Medicine, Linyi University, Linyi 276000, Shandong, China. Electronic address:
β-Carboline alkaloids are a broad class of indole alkaloids that were first isolated from Peganum harmala L., a traditional Chinese herbal remedy. β-Carboline alkaloids have been found to have many pharmacological activities, including anti-inflammatory, antioxidant, and anti-cancer properties.
View Article and Find Full Text PDFEnhanced Efficacy of Some Antibiotics in the Presence of Silver Nanoparticles Against Clinical Isolate of Recovered from Cystic Fibrosis Patients.
Int J Nanomedicine
November 2024
Translational and Clinical Research Institute, Newcastle University Medical School, Newcastle Upon Tyne, NE2 4HH UK.
Introduction: Given the increasing frequency of drug-resistant bacteria and the limited progress in developing new antibiotics, it is necessary to explore new methods of combating microbial infections. Nanoparticles, particularly silver nanoparticles (Ag-NPs), have shown exceptional antibacterial characteristics; however, elevated concentrations of Ag-NPs can produce noticeable levels of toxicity in mammalian cells.
Aim: This study examined the potential synergistic effect of combining a low dosage of Ag-NPs and anti-pseudomonas drugs against (ATCC strain) and eleven clinical isolates from cystic fibrosis patients.
Metabolite and mineral contents in root, seed, testa, stem and leaf of L.
Heliyon
November 2024
College of Chemistry and Chemical Engineering, Xinjiang Normal University, Xinjiang, 830000, China.
(
View Article and Find Full Text PDFMultianalytical investigation reveals psychotropic substances in a ptolemaic Egyptian vase.
Sci Rep
November 2024
Department of Chemical and Pharmaceutical Sciences, University of Trieste, via Licio Giorgieri 1, Trieste, 34127, Italy.
This study presents a comprehensive multimodal analytical study of an Egyptian ritual Bes-vase, of the 2nd century BCE employing cutting-edge proteomics, metabolomics, genetics techniques, and synchrotron radiation-based Fourier Transformed Infrared microSpectroscopy (SR µ-FTIR) to characterize organic residues of its content. We successfully identified the presence of various functional, bioactive, psychotropic, and medicinal substances, shedding light on the diverse components of a liquid concoction used for ritual practices in Ptolemaic Egypt. Using LC-MS/MS with a new methodological approach, we identified key proteins and metabolites, enabling the identification of botanical sources, confirmed by genetic sequences.
View Article and Find Full Text PDFFirst Report of Root Rot Caused by on Syrian rue () in China.
Plant Dis
November 2024
Chinese Academy of Agricultural Sciences Grassland Research Institute, Hohhot, Inner Mongolia, China;
Article Synopsis
- Syrian rue, a plant found in arid regions of China, is crucial for soil conservation and stabilization against sand encroachment and plays a key role in reclaiming wastelands.
- In 2023, a disease resembling root rot affected about 50% of Syrian rue plants in Inner Mongolia, causing symptoms like yellowing, wilting, and darkening of the roots' xylem.
- Researchers collected symptomatic samples, isolated a pathogen (designated LTP-5), and observed specific morphological characteristics of the fungal colonies grown in the lab, indicating its potential impact on Syrian rue's health and agricultural yield.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!