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| http://dx.doi.org/10.14744/AnatolJCardiol.2016.7185 | DOI Listing |
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IgG4-Related Arterial Disease: An Unusual Case of Aortitis.
J Rheumatol
December 2024
Eric Hachulla, MD, PhD, Hospital Center, Université de Lille, Institute for Translational Research in Inflammation (INFINITE), and Inserm, Lille; and CHU Lille, Service de Médecine Interne et Immunologie Clinique, Centre de référence des maladies autoimmunes systémiques rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France.
Comparative Analysis of Classification Criteria in IgG4-Related Disease and Evaluating Diagnostic Accuracy from a Retrospective Cohort in Clinical Practice.
Diagnostics (Basel)
November 2024
Department of Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain.
Introduction: We conducted a comprehensive comparative analysis of the Okazaki, Umehara, and American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for diagnosing immunoglobulin G4-related disease (IgG4-RD).
Materials And Methods: A retrospective study was conducted in a single tertiary hospital, using expert clinical judgment as the gold standard. We compared the diagnostic accuracy of the Okazaki, Umehara, and ACR/EULAR criteria in a cohort of 41 patients with suspected IgG4-RD.
Exploring cardiovascular involvement in IgG4-related disease: a case series approach with cardiovascular magnetic resonance.
Heart
January 2025
University of Oxford, Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK
Background: IgG4-related disease (IgG4-RD) is a relapsing-remitting, fibroinflammatory, multisystem disorder. Cardiovascular involvement from IgG4-RD has not been systematically characterised. In this study, we sought to evaluate consecutive patients with IgG4-RD using a detailed multiparametric cardiovascular magnetic resonance (CMR) imaging protocol.
View Article and Find Full Text PDFA rare case of IgG4-related aortitis in the thoracic aorta mimicking an intramural hematoma: navigating the diagnostic labyrinth.
J Cardiothorac Surg
October 2024
Division of Cardiothoracic Surgery, The Valley Hospital, 223 N Van Dien Ave, Ridgewood, NJ, 07450, USA.
Article Synopsis
- A 54-year-old woman was admitted with recurrent abdominal pain and new chest pain, leading to the discovery of a thoracic aortic aneurysm, suspected to involve intramural hematoma or aortitis.
- Initial conservative treatment was followed by surgical intervention after imaging suggested intramural hematoma, but surgery revealed severe aortitis without hematoma, indicating complex diagnostic challenges.
- Further examination identified IgG4-related disease linked to chronic lymphocytic leukemia (CLL), highlighting the need for a multidisciplinary approach and various diagnostic methods to accurately assess aortic conditions.
The immunological pathogenesis of IgG4-related disease categorized by clinical characteristics.
Immunol Med
September 2024
Department of Internal Medicine, Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan.
IgG4-related disease (IgG4-RD) is an immune disorder characterized by organ enlargement and fibrosis leading to functional impairment. Key immune cell subsets contributing to the pathogenesis of IgG4-RD include T follicular helper 2 cells (Tfh2), Tfh1, CX3CR1 + cytotoxic T cells (CX3CR1 + CTLs), Tregs and IgG4 + B cells. Tfh2 and Tregs are commonly involved in inducing IgG4 class-switching in this disease.
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