Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. immune cells, endothelial cells, fibroblasts, and mesenchymal stroma/stem cells (MSC)) via the extracellular matrix and soluble factors such as cytokines, chemokines, growth factors and various metabolites. Cell populations of the tumor microenvironment can interact directly and indirectly with cancer cells by mutually altering properties and functions of the involved partners. Particularly, mesenchymal stroma/stem cells (MSC) play an important role during carcinogenesis exhibiting different types of intercellular communication. Accordingly, this work focusses on diverse mechanisms of interaction between MSC and cancer cells. Moreover, some functional changes and consequences for both cell types are summarized which can eventually result in the establishment of a carcinoma stem cell niche (CSCN) or the generation of new tumor cell populations by MSC-tumor cell fusion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016940 | PMC |
| http://dx.doi.org/10.1186/s12964-016-0143-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The dynamic interaction of pediatric ALL cells and MSCs: influencing leukemic cell survival and modulating MSC β-catenin expression.
Histochem Cell Biol
January 2025
Department of Histology and Embryology, Faculty of Medicine, Ankara Yildirim Beyazit University, 06800, Ankara, Turkey.
Bone marrow mesenchymal stromal cells (BM-MSCs) are integral components of the bone marrow microenvironment, playing a crucial role in supporting hematopoiesis. Recent studies have investigated the potential involvement of BM-MSCs in the pathophysiology of acute lymphoblastic leukemia (ALL). However, the exact contribution of BM-MSCs to leukemia progression remains unclear because of conflicting findings and limited characterization.
View Article and Find Full Text PDFA framework for understanding the path to achieve high resilience of maritime supply chain.
Sci Rep
January 2025
College of Navigation, Jimei University, Xiamen, 361021, Fujian, China.
In recent years, a significant rise in international sudden risk events has resulted in impacts and disruptions to maritime supply chains (MSC). The resilience of maritime supply chains has garnered attention from the academic, industrial, and government sectors. The paper proposes a methodological framework based on the structural equation model (SEM), Necessary Condition Analysis (NCA), fuzzy set qualitative comparative analysis (fsQCA), and utilizes questionnaire data from the maritime industry in China to evaluate the resilience in MSC.
View Article and Find Full Text PDFAdvances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration.
Front Immunol
January 2025
Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Periodontal disease is a highly prevalent disease worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal disease can achieve good control of inflammation, it is difficult to regenerate the periodontal supporting tissues to achieve a satisfactory therapeutic effect. In recent years, due to the good tissue regeneration ability, the research on Mesenchymal stromal/stem cells (MSCs) and MSC-derived exosomes has been gradually deepened, especially its ability to interact with the microenvironment of the body in the complex immunoregulatory network, which has led to many new perspectives on the therapeutic strategies for many diseases.
View Article and Find Full Text PDFInterleukin-12 Inhibits Tumor Growth and Metastasis Promoted by Tumor-Associated Mesenchymal Stem Cells in Triple-Negative Breast Cancer.
Cell J
January 2025
Department of Molecular Medicine, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. Email:
Objective: The aim of this study was to understand the interactions between tumor-associated mesenchymal stem cells (TA-MSCs) and triple-negative breast cancer (TNBC) cells, which appear to be necessary for developing effective therapies.
Materials And Methods: In this experimental study, MDA-MB-231 and 4T1 TNBC cells were co-cultured with bone marrow-derived MSCs, and TA-MSCs conditioned media (CM) were collected. TA-MSC CM-treated TNBC cells were subjected to migration and invasion assays.
The moral self in formation: Caregiver emotional availability and early prosocial behavior predict preschoolers' moral self-concept.
Dev Psychol
January 2025
Department of Psychology, Ludwig-Maximilians-Universitat Munchen.
During early childhood, children develop a moral self-concept (MSC), reflecting the representation of their own moral behavioral preferences. Little is known about the developmental processes that relate to the emergence of the MSC. This longitudinal study followed participants from infancy to preschool age ( = 99-139; 49%-55% girls, 45%-51% boys, mostly Caucasian).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!