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Community awareness regarding smokeless tobacco (Shamma) as a cause of oral cancer in Jazan region, Saudi Arabia: A cross-sectional study.
J Family Med Prim Care
November 2024
Abu Arish Chest Hospital, Jazan, Saudi Arabia.
Introduction: Oral cancer has emerged as a significant public health issue, with 90% of instances because of avoidable causes. Smokeless tobacco usage is thought to be a substantial source of cytological alterations in the oral mucosa, and snuff (Shamma) is often used in Saudi Arabia. In this study, we investigated community awareness of Shamma as a cause of oral cancer in the Jazan region's general population.
View Article and Find Full Text PDFDiseases with oral malignant potential: Need for change to inform research, policy, and practice.
J Oral Pathol Med
September 2024
Melbourne Dental School, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Article Synopsis
- The manuscript critiques the existing classification of oral potentially malignant disorders, arguing that labeling many cases as precancerous is misleading since most do not progress to oral cancer.
- It calls for a reclassification system that better reflects the actual risk of malignancy and proposes new categories for different levels of risk, including Oral Precancerous Diseases and Systemic Conditions with Oral Malignant Potential.
- The authors aim to improve diagnostic and management strategies, reducing overdiagnosis and the associated burden on patients, while providing practical examples for research and clinical application.
Impact of khat (Catha edulis) and oral contraceptive use on telomerase levels and tumor suppressor genes p53 and p21 in normal subjects and breast cancer patients.
Sci Rep
July 2024
Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Republic of Yemen.
This study aimed to evaluate the effects of oral contraceptive (OC) use, khat chewing, and their combined effect on telomerase level and tumor suppressor genes, p53 and p21 in breast cancer (BC) patients and normal volunteers. 140 Yemeni women aged 25-40 years old enrolled, 60 newly diagnosed pretreated BC patients, and 80 control subjects. Venous blood (5 ml) was collected and the results showed BC patients to have significantly raised levels of telomerase, p53, and p21 compared to the control group.
View Article and Find Full Text PDFKhat use and related determinants among pregnant women within Haramaya, Ethiopia: a mixed methods study.
Front Glob Womens Health
May 2024
School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Introduction: Khat, a green leafy plant grown in East Africa and throughout the Arabian Peninsula, is chewed for its psychoactive and amphetamine-like effects, serving as a significant aspect of culture, economic livelihood, and global trade. Khat consumption during pregnancy has been associated with adverse effects, including anemia, premature rupture of membranes, and low birth weight, among others.
Methods: This cross-sectional, explanatory sequential mixed methods study was conducted in the Haramaya District of eastern Ethiopia using a questionnaire and focus group discussions.
Spatiotemporal Distribution, Time to Treatment Outcome Clustering and Determinants of Esophageal Cancer in Ethiopia, a Scoping Study.
Cancer Control
May 2024
Department of preventive Medicine, School of Public Health Addis Ababa University, Ethiopia.
Introduction: Esophageal cancer was the eighth and sixth leading cause of morbidity of all cancers in the world, and the 15th and 12th in Ethiopia, respectively. There is a lack of comprehensive data regarding Ethiopia's esophageal cancer hotspot, treatment outcome clustering, and other factors.
Objective: This scoping review was designed to understand the extent and type of existing evidence regarding spatiotemporal distribution, time to treatment outcome clustering, and determinants of esophageal cancer in Ethiopia up to March 28, 2023.
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