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http://dx.doi.org/10.1080/0284186X.2016.1220678 | DOI Listing |
Acta Oncol
December 2016
a Department of Internal Medicine , Máxima Medical Center, Veldhoven , The Netherlands.
J Hand Surg Eur Vol
November 2011
Blond McIndoe Laboratories, Biomedicine, University of Manchester, Manchester Academic Health Science Centre, UK.
Following distal nerve injury significant sensory neuronal cell death occurs in the dorsal root ganglia, while after a more proximal injury, such as brachial plexus injury, a sizeable proportion of spinal motoneurons also undergo cell death. This phenomenon has been undervalued for a long time, but it has a significant role in the lack of functional recuperation, as neuronal cells cannot divide and be replaced, hence the resulting nerve regeneration is usually suboptimal. It is now accepted that this cell death is due to apoptosis, as indicated by analysis of specific genes involved in the apoptotic signalling cascade.
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