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Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.
Eur J Nucl Med Mol Imaging
December 2024
Molecular Imaging and Therapy Laboratory, Vrije Universiteit Brussel, Brussels, Belgium.
Purpose: While immunotherapy has revolutionized the oncology field, variations in therapy responsiveness limit the broad applicability of these therapies. Diagnostic imaging of immune cell, and specifically CD8 T cell, dynamics could allow early patient stratification and result in improved therapy efficacy and safety. In this study, we report the development of a nanobody-based immunotracer for non-invasive SPECT and PET imaging of human CD8 T-cell dynamics.
View Article and Find Full Text PDFEngineered Chlorella vulgaris improves bioethanol production and promises prebiotic application.
World J Microbiol Biotechnol
July 2024
Department of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
Microalgal biomass for biofuel production, integration into functional food, and feed supplementation has generated substantial interest worldwide due to its high growth rate, non-competitiveness for agronomic land, ease of cultivation in containments, and presence of several bioactive molecules. In this study, genetic engineering tools were employed to develop transgenic lines of freshwater microalga Chlorella vulgaris with a higher starch content, by up-regulating ADP-glucose pyrophosphorylase (AGPase), which is a rate-limiting enzyme in starch biosynthesis. Expression of the Escherichia coli glgC (AGPase homolog) gene in C.
View Article and Find Full Text PDFModelling daisy quorum drive: A short-term bridge across engineered fitness valleys.
PLoS Genet
May 2024
Biodiversity Research Center, Department of Zoology, University of British Columbia, Vancouver BC, Canada.
Engineered gene-drive techniques for population modification and/or suppression have the potential for tackling complex challenges, including reducing the spread of diseases and invasive species. Gene-drive systems with low threshold frequencies for invasion, such as homing-based gene drive, require initially few transgenic individuals to spread and are therefore easy to introduce. The self-propelled behavior of such drives presents a double-edged sword, however, as the low threshold can allow transgenic elements to expand beyond a target population.
View Article and Find Full Text PDFThe missing hallmark of health: psychosocial adaptation.
Cell Stress
March 2024
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.
The eight biological hallmarks of health that we initially postulated (. 2021 Jan 7;184(1):33-63) include features of spatial compartmentalization (integrity of barriers, containment of local perturbations), maintenance of homeostasis over time (recycling & turnover, integration of circuitries, rhythmic oscillations) and an array of adequate responses to stress (homeostatic resilience, hormetic regulation, repair & regeneration). These hallmarks affect all eight somatic strata of the human body (molecules, organelles, cells, supracellular units, organs, organ systems, systemic circuitries and meta-organism).
View Article and Find Full Text PDFCas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements.
Nat Commun
March 2024
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Sophisticated gene circuits built by synthetic biology can enable bacteria to sense their environment and respond predictably. Engineered biosensing bacteria outfitted with such circuits can potentially probe the human gut microbiome to prevent, diagnose, or treat disease. To provide robust biocontainment for engineered bacteria, we devised a Cas9-assisted auxotrophic biocontainment system combining thymidine auxotrophy, an Engineered Riboregulator (ER) for controlled gene expression, and a CRISPR Device (CD).
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