Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease.

Afr Health Sci

Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou 510800, China.

Published: June 2016

Objective: This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.

Method: In this study, 24 ESRD patients and 24 healthy controls were included.

Results: In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P<0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18±21 vs 7.78±1.31; P<0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P<0.01).

Conclusion: VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994540PMC
http://dx.doi.org/10.4314/ahs.v16i2.14DOI Listing

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