AI Article Synopsis
- The study investigates how colloidal microRNA-functionalized nanoparticles break down under specific light conditions using time-dependent second harmonic generation (SHG) measurements.
- Model drug delivery systems were developed using oligonucleotides attached to silver or polystyrene nanoparticles, exhibiting optimal release efficiency with 365 nm light and showing that silver nanoparticles are significantly more effective than polystyrene ones.
- SHG measurements were validated by additional techniques like spectroscopy and fluorimetry, proving SHG to be an effective method for exploring the photocleaving dynamics influenced by plasmon enhancements in these systems.
Article Abstract
The photocleaving dynamics of colloidal microRNA-functionalized nanoparticles are studied using time-dependent second harmonic generation (SHG) measurements. Model drug-delivery systems composed of oligonucleotides attached to either silver nanoparticles or polystyrene nanoparticles using a nitrobenzyl photocleavable linker are prepared and characterized. The photoactivated controlled release is observed to be most efficient on resonance at 365 nm irradiation, with pseudo-first-order rate constants that are linearly proportional to irradiation powers. Additionally, silver nanoparticles show a 6-fold plasmon enhancement in photocleaving efficiency over corresponding polystyrene nanoparticle rates, while our previous measurements on gold nanoparticles show a 2-fold plasmon enhancement compared to polystyrene nanoparticles. Characterizations including extinction spectroscopy, electrophoretic mobility, and fluorimetry measurements confirm the analysis from the SHG results. The real-time SHG measurements are shown to be a highly sensitive method for investigating plasmon-enhanced photocleaving dynamics in model drug delivery systems.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124014 | PMC |
| http://dx.doi.org/10.1021/acs.langmuir.6b02538 | DOI Listing |
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