Modern implantable cardioverter/defibrillator (ICD) systems offer a multitude of algorithms to optimize performance in sensing and tachycardia detection even in difficult circumstances (e. g., ventricular tachycardia during supraventricular tachycardia, fine ventricular fibrillation with intermittent undersensing), to reliably discriminate sustained ventricular tachyarrhythmia from noise, nonsustained and supraventricular tachyarrhythmia, and to limit shock therapy only to those arrhythmias that definitely need to be treated by a shock. A disadvantage of these multiple algorithms is the complexity of annotated tracings that makes it sometimes difficult to understand why the ICD did what it did. If a tachycardia classification was wrong, it may be thus difficult to find the best way to reprogram the device to avoid another misclassification. This review explains in detail the algorithms used for tachycardia detection, discrimination, and prevention of inappropriate therapy in single- and dual-chamber ICDs manufactured by St. Jude Medical. Knowledge of these features may help to optimize ICD treatment in patients fitted with these devices.
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http://dx.doi.org/10.1007/s00399-016-0455-1 | DOI Listing |
Nanoscale
January 2025
Division of Materials Theory, Department of Physics and Astronomy, Uppsala University, Sweden.
Amino acids are fundamental building blocks of proteins, playing critical roles in medical diagnostics, environmental monitoring, and biomarker identification. The development of nanoscale electronic sensors capable of single-amino-acid recognition has gained significant attention due to their potential for label-free, real-time detection. In this study, we investigate the electronic transport properties of amino acids in two gold-based nanodevices with distinct architectures: a gold nanojunction and a gold-capacitor system.
View Article and Find Full Text PDFTransl Lung Cancer Res
December 2024
Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Background: Spread through air spaces (STAS) in lung adenocarcinoma (LUAD) is a distinct pattern of intrapulmonary metastasis where tumor cells disseminate within the pulmonary parenchyma beyond the primary tumor margins. This phenomenon was officially included in the World Health Organization (WHO)'s classification of lung tumors in 2015. STAS is characterized by the spread of tumor cells in three forms: single cells, micropapillary clusters, and solid nests.
View Article and Find Full Text PDFBackground: Aneurysmal subarachnoid hemorrhage (aSAH) causes systemic changes that contribute to delayed cerebral ischemia (DCI) and morbidity. Circulating metabolites reflecting underlying pathophysiological mechanisms warrant investigation as biomarker candidates.
Methods: Blood samples, prospectively collected within 24 hours (T1) of admission and 7-days (T2) post ictus, from patients with acute aSAH from two tertiary care centers were retrospectively analyzed.
J Cogn
January 2025
University of Trier, Department of Cognitive Psychology, Germany.
Inhibition of return (IOR) refers to a location repetition cost typically observed when signaling the detection of or localizing sequentially presented stimuli repeating or changing their location. In discrimination tasks, however, IOR is often reduced or even absent; here, effects of binding and retrieval are thought to take place. Information is bound into an event file, which upon feature repetition causes retrieval, leading to partial repetition costs.
View Article and Find Full Text PDFFront Neurol
January 2025
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
Objectives: This study aimed to assess the psychometric properties of the Chinese version of the Stay Independent Questionnaire (C-SIQ) in evaluating individuals with stroke.
Design: The study adopted a cross-sectional design.
Setting: The research was conducted at a university-based neurorehabilitation center.
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