AI Article Synopsis
- Bevacizumab is used in conjunction with other drugs like 5-fluorouracil, leucovorin, and oxaliplatin or irinotecan to treat metastatic colorectal cancer, offering a less toxic alternative to traditional chemotherapy.
- Despite its benefits, bevacizumab can lead to severe side effects, including serious complications like pulmonary embolism and gastrointestinal perforation.
- This report examines a specific case of a patient with advanced colon cancer experiencing these adverse effects, highlighting the associated risks, causes, and common symptoms of such complications.
Article Abstract
Bevacizumab is an important component in the treatment of metastatic colorectal cancer when used with 5-fluorouracil, leucovorin and oxaliplatin or irinotecan. As a molecular target agent, it is considered to be less toxic than traditional chemotherapy; however, bevacizumab has been shown to cause serious, life-threatening adverse effects. The following report describes a case of bevacizumab-associated pulmonary embolism with simultaneous gastrointestinal perforation in a patient with stage IV adenocarcinoma of the descending colon. This case report and literature review describes the risk factors, etiology, and typical presentation of bevacizumab-induced gastrointestinal perforation and pulmonary embolism.
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| http://dx.doi.org/10.1177/1078155216667637 | DOI Listing |
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