Background: Dengue is a major mosquito-borne viral disease and an important public health problem. Identifying which factors are important determinants in the risk of dengue infection is critical in supporting and guiding preventive measures. In South-East Asia, half of all reported fatal infections are recorded in Indonesia, yet little is known about the epidemiology of dengue in this country.
Methodology/principal Findings: Hospital-reported dengue cases in Banyumas regency, Central Java were examined to build Bayesian spatial and spatio-temporal models assessing the influence of climatic, demographic and socio-economic factors on the risk of dengue infection. A socio-economic factor linking employment type and economic status was the most influential on the risk of dengue infection in the Regency. Other factors such as access to healthcare facilities and night-time temperature were also found to be associated with higher risk of reported dengue infection but had limited explanatory power.
Conclusions/significance: Our data suggest that dengue infections are triggered by indoor transmission events linked to socio-economic factors (employment type, economic status). Preventive measures in this area should therefore target also specific environments such as schools and work areas to attempt and reduce dengue burden in this community. Although our analysis did not account for factors such as variations in immunity which need further investigation, this study can advise preventive measures in areas with similar patterns of reported dengue cases and environment.
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http://dx.doi.org/10.1371/journal.pntd.0004964 | DOI Listing |
Stat Med
February 2025
Departamento de Estadística, Pontificia Universidad Católica de Chile, Santiago, Chile.
More than half of the world's population is exposed to mosquito-borne diseases, leading to millions of cases and hundreds of thousands of deaths every year. Analyzing this type of data is complex and poses several interesting challenges, mainly due to the usually vast geographic area involved, the peculiar temporal behavior, and the potential correlation between infections. Motivation for this work stems from the analysis of tropical disease data, namely, the number of cases of dengue and chikungunya, for the 145 microregions in Southeast Brazil from 2018 to 2022.
View Article and Find Full Text PDFTrop Med Infect Dis
January 2025
Department of Research, PMO, Ministry Branch in Makkah Region, Ministry of Health (MOH), Makkah 21955, Saudi Arabia.
Dengue fever is caused by four common serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4). Patients infected with one serotype may develop lifelong serotype-specific protective immunity. However, they remain susceptible to reinfection with the other serotypes, often increasing the risk of severe forms of dengue.
View Article and Find Full Text PDFTrop Med Infect Dis
January 2025
Department of Medicine and Health Sciences, University of Sonora, Ciudad Obregon 85199, Mexico.
Background: Rocky Mountain spotted fever (RMSF) is a challenge for physicians because the disease can mimic other endemic febrile illnesses, such as dengue and COVID-19. The comparison of their main clinical and epidemiological manifestations in hospitalized children can help identify characteristics that improve empirical suspicion and timely therapeutic interventions.
Methods: A cross-sectional study was conducted on a series of patients aged 0 to 18 years, hospitalized between 2015 and 2022, with a diagnosis of RMSF, dengue, or COVID-19.
Trop Med Infect Dis
January 2025
Centro de Atención y Diagnóstico de Enfermedades Infecciosas (CDI), Fundación INFOVIDA, Cra. 37 No. 51-126, Bucaramanga 680003, Colombia.
Dengue infection has been associated with oxidative stress (OS) induction; however, whether such a response predicts the development of complications remains unknown. We conducted a case-control study (1:2 ratio) nested within a cohort of febrile patients with a presumptive or confirmed diagnosis of dengue. Incident cases were patients who developed hypotension or severe bleeding during the follow-up, whereas controls did not.
View Article and Find Full Text PDFIJID Reg
March 2025
Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Objectives: Arboviruses pose significant public health threats worldwide, with Southeast Asia being a hotspot for these infections. This study aimed to reassess the incidence of dengue, Zika, and chikungunya viruses in patients clinically diagnosed with dengue in East Java, Indonesia in 2023.
Methods: The study included 108 patients admitted to hospitals in Jember, with blood samples collected on admission.
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