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ICD-11 personality disorder features in the danish general population: Cut-offs and prevalence rates for severity levels.
Psychiatry Res
October 2023
University of Otago, Dunedin, New Zealand.
Introduction: Prevalence rates and correlates of personality disorders (PD) are relevant to health care policy and planning.
Objectives: To present normative data for self-reported ICD-11 personality disorder (PD) features including tentative cut-off scores and prevalence rates for severity levels along with psychosocial correlates.
Methods: The Personality Disorder Severity ICD-11 (PDS-ICD-11) scale and criterion measures of impairment were administered to a social-demographically stratified sample of Danish citizens (N = 8,941) of which 3,044 delivered complete data.
Cold Acclimation and Deacclimation of Two Garden Rose Cultivars Under Controlled Daylength and Temperature.
Front Plant Sci
March 2020
Department of Plants and Crops, Ghent University, Ghent, Belgium.
Low temperature stress is an important abiotic stress for garden roses in northern regions. Two garden rose cultivars ('Dagmar Hastrup' and 'Chandos Beauty') were selected to study the role of dehydrin and of carbohydrate metabolism during cold acclimation and deacclimation under the controlled daylength and temperature. The presence of bud dormancy was also observed as this could prevent budburst during warm spells.
View Article and Find Full Text PDFSeasonal changes in cold hardiness and carbohydrate metabolism in four garden rose cultivars.
J Plant Physiol
January 2019
Department of Plants and Crops, Ghent University, Coupure links 653, 9000 Gent, Belgium. Electronic address:
We studied metabolic adaptations to cold stress in roses and identified genes in the carbohydrate pathway during acclimation and deacclimation. A field experiment with four rose cultivars belonging to different USDA plant hardiness zones was set up in Melle, Belgium (51° 0' N, 3° 48' E). The more cold-hardy cultivars ('Dagmar Hastrup' and 'John Cabot') reached their lowest LT value in December, indicating a rapid acclimation after the first occurrence of frost.
View Article and Find Full Text PDFThe EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.
Mol Metab
February 2018
Novo Nordisk A/S, Diabetes Research, Department of Islet & Stem Cell Biology, Novo Nordisk Park, 2760, Maaloev, Denmark. Electronic address:
Objective: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening platform for identification of novel anti-diabetic drug candidates.
Methods: EndoC-βH1 was transplanted into mice for validation of in vivo functionality. Insulin secretion was evaluated in cells cultured as monolayer and as pseudoislets, as well as in diabetic mice.
The effect of duration of untreated psychosis and treatment delay on the outcomes of prolonged early intervention in psychotic disorders.
NPJ Schizophr
September 2017
Copenhagen Mental Health Centre, Capital Region, Copenhagen, Denmark.
Unlabelled: The duration of untreated psychosis (DUP) has been shown to have an effect on outcome after first-episode psychosis. The premise of specialized early intervention (SEI) services is that intervention in the early years of illness can affect long-term outcomes. In this study, we investigate whether DUP affects treatment response after 5 years of SEI treatment compared to 2 years of SEI treatment.
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