Complete Sequencing of Plasmids Containing blaOXA-163 and blaOXA-48 in Escherichia coli Sequence Type 131.

OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in Escherichia coli sequence type 131 (ST131). We report the structures of the first fully sequenced bla plasmid and of two other bla plasmids in this lineage. bla was located on a 71-kb IncN plasmid with other resistance genes. bla was present on IncL/M plasmids, genetically similar to other bla plasmid sequences, and consistent with interspecies/interlineage spread. The presence of bla genes on epidemic plasmids in ST131 is of concern.