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Signaling events driving Aspergillus fumigatus-induced eosinophil activation.
Int J Med Microbiol
December 2024
Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen and Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Germany; FAU Profile Center Immunomedicine (FAU I-MED), Germany. Electronic address:
Allergic bronchopulmonary aspergillosis is an incurable disease caused by the environmental mold Aspergillus fumigatus. This hypersensitivity pneumonia is characterized by an inflammatory type 2 immune response, accompanied by influx of eosinophils into the lung. To investigate the mode of action of eosinophils and the signaling events triggered by A.
View Article and Find Full Text PDFTrends in the Treatment of Allergic Bronchopulmonary Aspergillosis.
Ann Am Thorac Soc
December 2024
Boston University, Boston, Massachusetts, United States.
Refractory phenotype of -sensitized asthma with bronchiectasis and allergic bronchopulmonary aspergillosis.
J Allergy Clin Immunol Glob
February 2025
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Background: Sensitization to mucus plugs, and bacterial colonization may coexist and relate to a refractory phenotype during follow-up in asthma with bronchiectasis and allergic bronchopulmonary aspergillosis (ABPA).
Objective: This study aimed to clarify the features of -sensitized refractory asthma with bronchiectasis and determine the refractory phenotype in this population and ABPA.
Methods: This study included cases of the oldest available -specific IgE data and chest computed tomography images from a nationwide survey of refractory asthma with bronchiectasis.
A multidimensional grading system for ABPA treatment escalation within the first year: The HEID score.
World Allergy Organ J
December 2024
Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Peking University, Beijing, China.
Background: Susceptibility to relapse is an important feature of allergic bronchopulmonary aspergillosis (ABPA); early identification of patients at high risk of relapse is urgently needed. A practical score that classifies the severity of ABPA according to its prognosis is not available.
Methods: We retrospectively reviewed patients with a diagnosis of ABPA at our hospital between January 2010 and December 2022.
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