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Characterizing the underlying microangiopathy of deep cerebellar intracerebral hemorrhage.
J Neurol
January 2025
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Introduction: While cerebral amyloid angiopathy is likely responsible for intracerebral hemorrhage (ICH) occurring in superficial (grey matter, vermis) cerebellar locations, it is unclear whether hypertensive arteriopathy (HA), the other major cerebral small vessel disease (cSVD), is associated with cerebellar ICH (cICH) in deep (white matter, deep nuclei, cerebellar peduncle) regions. We tested the hypothesis that HA-associated neuroimaging markers are significantly associated with deep cICH compared to superficial cICH.
Patients And Methods: Brain MRI scans from consecutive non-traumatic cICH patients admitted to a referral center were analyzed for cSVD markers.
Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct.
Neuroradiology
January 2025
Comprehensive Stroke Center, Department of Neuroscience, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain.
Purpose: Fluid exchanges between perivascular spaces (PVS) and interstitium may contribute to the pathophysiology of small vessel disease (SVD). We aimed to analyze water diffusivity measures and their relationship with PVS and other SVD imaging markers.
Methods: We enrolled 50 consecutive patients with a recent small subcortical infarct.
Retinal vasculature changes as indicators of imaging signs of cerebral small vessel disease: A community-based, cross-sectional study of older adults.
J Clin Neurosci
January 2025
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, China. Electronic address:
Objectives: This study investigated the correlation between retinal vasculature and cerebral small vessel disease (CSVD) imaging markers, providing new evidence for the retina-brain association.
Methods: Two hundred and thirty-nine participants aged 55-85 were enrolled in the study. CSVD indicators, encompassing white matter hyperintensities (WMHs), lacunes (LAs), cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVSs), were assessed.
Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study.
JAMA Netw Open
January 2025
Alzheimer Center Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels.
Objective: To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age.
Design, Setting, And Participants: This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]).
Monogenic causes of cerebral small vessel disease- models for vascular cognitive impairment and dementia?
Curr Opin Psychiatry
January 2025
Centre for Healthy Brain Ageing, University of New South Wales.
Purpose Of Review: Recent advancements in molecular biomarkers and therapeutic options for Alzheimer's disease have brought into focus the need for greater progress in the second most common cause of dementia, vascular cognitive impairment and dementia (VCID). We examine how the study of monogenic causes of VCID has contributed to the understanding of its pathophysiology and potential biomarker and treatment research.
Recent Findings: It is widely accepted that conditions which disrupt the cerebral small vessels contribute to vascular pathologies including stroke and cerebral microbleeds, ultimately leading to vascular cognitive impairment and dementia.
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