In this study, we explored possibility of increasing the protective efficacy of our novel influenza viral vector based B. abortus vaccine (Flu-BA) in pregnant heifers by adapting an innovative method of vaccine delivery. We administered the vaccine concurrently via the conjunctival and subcutaneous routes to pregnant heifers, and these routes were previously tested individually. The Flu-BA vaccination of pregnant heifers (n=9) against a challenge B. abortus 544 infection provided protection from abortion, infection of heifers and fetuses/calves by 88.8%, 100% and 100%, respectively (alpha=0.004-0.0007 vs. negative control; n=7). Our candidate vaccine using this delivery method provided slightly better protection than the commercial B. abortus S19 vaccine in pregnant heifers (n=8), which provided protection from abortion, infection of heifers and fetuses/calves by 87.5%, 75% and 87.5%, respectively. This improved method of the Flu-BA vaccine administration is highly recommended for the recovery of farms which has high prevalence of brucellosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vaccine.2016.08.072 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genomic Regions Associated with Spontaneous Abortion in Holstein Heifers.
Genes (Basel)
November 2024
Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
Article Synopsis
- - The dairy industry needs efficient reproduction for successful milk production, with spontaneous abortion (SA) affecting different rates between heifers bred by artificial insemination (4.5%) and those receiving embryo transfer (31.6%).
- - A genome-wide association analysis (GWAA) identified 216 loci and 413 candidate genes linked to SA in artificially inseminated Holstein heifers, while no significant loci were found for embryo transfer recipients.
- - The discovered genetic loci related to SA in AI heifers can potentially aid in decreasing fetal loss through genomic selection strategies.
Late gestation heat stress alters O regulation in placenta and neonatal heifers.
Placenta
January 2025
Department of Animal Sciences, University of Florida, Gainesville, USA. Electronic address:
Introduction: Maternal hyperthermia (i.e. heat stress) can adversely affect placental development and function, with severity varying based on pregnancy stage.
View Article and Find Full Text PDFLate-gestation heat stress alters placental structure and function in multiparous dairy cows.
J Dairy Sci
January 2025
Department of Animal Sciences, University of Florida, Gainesville, FL 31608. Electronic address:
The placenta plays a pivotal role in fetal development and the dam's subsequent lactation performance, because it facilitates nutrient transfer, heat dissipation, and gas exchange with the growing fetus, and regulates key hormones essential for mammary gland development. Heat stress experienced during gestation and lactation can significantly reduce the placenta's capacity to perform these critical functions. To investigate the impact of heat stress, trials were conducted over the summer months of 2020, 2022, and 2023 in Florida.
View Article and Find Full Text PDFEfficacy of Vaccination with the DIVENCE Vaccine Against Bovine Viral Diarrhea Virus Types 1 and 2 in Terms of Fetal Protection.
Vet Med (Auckl)
December 2024
Hipra Scientific S.L.U., R&D Department, Amer, Spain.
Purpose: To demonstrate the efficacy of DIVENCE, a vaccine against BVDV types 1 and 2 (BVDV-1 and BVDV-2) transplacental infection, following a booster regimen in heifers.
Materials And Methods: Calves of two-to-three months of age were given two intramuscular doses three weeks apart and a booster vaccine six months later. Efficacy was evaluated by means of a challenge with virulent BVDV-1 or BVDV-2 administered via the intranasal route at 85 days of gestation.
Relationship between plasma anti-Müllerian hormone concentrations in female Holstein calves immediately after birth and milk yield and composition in dams during early to mid gestation.
JDS Commun
November 2024
Field Center of Animal Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan.
The energy status of dams during the early stages of gestation may affect ovarian reserves. It was hypothesized that greater milk yield and composition during the early stages of gestation may suppress the number of primordial follicles in the fetuses of dairy cattle. This study aimed to evaluate the anti-Müllerian hormone (AMH), used as an indicator of ovarian reserves, in female Holstein calves immediately after birth.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!