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Dyshidrosiform Bullous Pemphigoid: A Palmar Variant of a Common Disease.
Cureus
December 2024
Dermatology, Corewell Health Farmington Hills Hospital, Farmington Hills, USA.
Dyshidrosiform bullous pemphigoid (DBP) is a rare variant of bullous pemphigoid (BP) that mainly affects elderly patients and presents with tense bullae formation on the palms, soles, or both palms and soles. This case report describes an 87-year-old woman who was evaluated in the hospital for a month-long erythematous and pruritic rash on most of her body that eventually manifested into tense blisters on the palms. DBP can pose a challenge to clinicians as it can resemble a variety of different vesicular diseases.
View Article and Find Full Text PDFResolution of Bullous Pemphigoid Following Lung Cancer Resection: A Case of Paraneoplastic Pemphigoid.
Cureus
November 2024
Department of Dermatology, JR Sapporo Hospital, Sapporo, JPN.
Bullous pemphigoid (BP) is a chronic autoimmune disorder characterized by subepidermal blister formation, primarily affecting elderly individuals. While BP has been associated with malignancies, the exact nature of this relationship remains unclear. We report the case of a 72-year-old man who presented with pruritic cutaneous lesions, including tense vesicles and bullae and was diagnosed with BP.
View Article and Find Full Text PDFGestational Pemphigoid-From Molecular Mechanisms to Clinical Outcomes: A Case Report and Review of Literature.
Life (Basel)
November 2024
Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Gestational pemphigoid is a rare, autoimmune, subepidermal bullous disease with an incidence of 1 in 50,000 pregnancies, displaying itself through pruritic erythema and urticarial papules and plaques that evolve into tense bullae. Histopathological findings consist of subepidermal vesicles with perivascular eosinophils and lymphocytes, and direct immunofluorescence reveals C3 complement and, more rarely, IgG in a linear band along the basement membrane. The course is usually self-limiting within 6 months after delivery but, later, can be triggered by subsequent pregnancies, menstruation, or treatment with oral contraceptives.
View Article and Find Full Text PDFAtypical Presentation of Severe Bullous Pemphigoid: A Case Report.
S D Med
August 2024
Department of Internal Medicine, University of South Dakota Sanford School of Medicine.
Article Synopsis
- Bullous pemphigoid (BP) is an autoimmune blistering disorder characterized by tense blisters and severe itching, often diagnosed through skin biopsies showing specific changes.
- This case report highlights an atypical BP presentation, where symptoms mimicked a herpes zoster infection before proper diagnosis led to the correct treatment with steroids and antibiotics.
- The report emphasizes the importance of recognizing BP in patients with widespread itching and skin lesions, to ensure timely and effective treatment.
Linear IgA bullous dermatosis associated with immunotherapy.
Dermatol Online J
December 2023
Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Article Synopsis
- Linear IgA bullous dermatosis (LABD) is a rare autoimmune skin condition characterized by blisters caused by IgA autoantibodies, and can resemble bullous pemphigoid (BP), which is due to IgG and IgE autoantibodies.
- A case study of a 67-year-old woman with metastatic ovarian cancer showed new blistering skin lesions after she started immunotherapy, which were diagnosed as LABD based on skin biopsy results.
- The patient’s condition did not improve with prednisone but significantly healed after starting dapsone, emphasizing the need for accurate diagnosis through histology and immunofluorescence to guide effective treatment without halting immunotherapy.
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