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Quality, topics, and demographic trends of animal systematic reviews - an umbrella review.
J Transl Med
January 2025
Center for Reproducible Science, University of Zurich, Zurich, Switzerland.
Background: Animal systematic reviews are critical to inform translational research. Despite their growing popularity, there is a notable lack of information on their quality, scope, and geographical distribution over time. Addressing this gap is important to maintain their effectiveness in fostering medical advancements.
View Article and Find Full Text PDFSchizoLMNet: a modified lightweight MobileNetV2- architecture for automated schizophrenia detection using EEG-derived spectrograms.
Phys Eng Sci Med
January 2025
Department of Electronics and Communication Engineering, Vishnu Institute of Technology, Bhimavaram, Andhra Pradesh, 534202, India.
Article Synopsis
- Schizophrenia (SZ) is a complex mental disorder that affects various aspects of a person's functioning and is typically diagnosed based on subjective evaluations by psychiatrists, which can lead to biases and inaccuracies.
- A new model called SchizoLMNet, which uses modified MobileNetV2 architecture, is introduced to diagnose SZ more effectively by analyzing EEG signals transformed into spectrogram images, boasting high accuracy rates in distinguishing between SZ and healthy individuals.
- This innovative framework seeks to advance into real-time clinical applications using mobile technology, enhancing communication between medical professionals and patients to improve SZ management.
Facial Emotion Recognition Ability in Individuals with Remitted Schizophrenia in Comparison to Healthy Population: A Cross-Sectional Study.
Indian J Psychol Med
January 2025
Dept. of Psychiatry, VMMC and Safdarjung Hospital, New Delhi, India.
Background: Facial emotion recognition is one of the significant domains of social cognition that underlie social interactions. These deficits can influence the functional outcome in individuals with schizophrenia by impairing judgment toward others and reducing their capability to function. We aimed to assess the facial emotion recognition deficits in individuals with schizophrenia in comparison to healthy individuals and find their association with clinical and demographic profiles.
View Article and Find Full Text PDFEfficacy and safety of iclepertin (BI 425809) with adjunctive computerized cognitive training in patients with schizophrenia.
Schizophr Res Cogn
June 2025
Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA.
Unlabelled: Despite significant patient burden, there are no approved pharmacotherapies to treat symptoms of cognitive impairment associated with schizophrenia (CIAS). This double-blind, placebo-controlled, parallel-group Phase II trial assessed the efficacy and safety of pharmacological augmentation of at-home computerized cognitive training (CCT) with iclepertin (BI 425809, a glycine transporter-1 inhibitor). Participants with schizophrenia (aged 18-50 years) on stable antipsychotic therapy, who were compliant with CCT during the run-in period, were enrolled.
View Article and Find Full Text PDFPreventing disease progression in schizophrenia: What are we waiting for.
J Psychiatr Res
December 2024
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Despite research advances and progress in health care, schizophrenia remains a debilitating and costly disease. Onset occurs typically during youth and can lead to a relapsing and ultimately chronic course with persistent symptoms and functional impairment if not promptly and properly treated. Consequently, over time, schizophrenia causes substantial distress and disability for patients, their families and accrues to a collective burden to society.
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