Large-scale microparticle arrays (LSMAs) are key for material science and bioengineering applications. However, previous approaches suffer from trade-offs between scalability, precision, specificity and versatility. Here, we present a porous microwell-based approach to create large-scale microparticle arrays with complex motifs. Microparticles are guided to and pushed into microwells by fluid flow through small open pores at the bottom of the porous well arrays. A scaling theory allows for the rational design of LSMAs to sort and array particles on the basis of their size, shape, or modulus. Sequential particle assembly allows for proximal and nested particle arrangements, as well as particle recollection and pattern transfer. We demonstrate the capabilities of the approach by means of three applications: high-throughput single-cell arrays; microenvironment fabrication for neutrophil chemotaxis; and complex, covert tags by the transfer of an upconversion nanocrystal-laden LSMA.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173431 | PMC |
| http://dx.doi.org/10.1038/nmat4747 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Auto-Deposited Microparticle Composite Coating for Low-Cost and Efficient Daytime Radiative Cooling.
ACS Appl Mater Interfaces
January 2025
School of Energy Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.
Radiative cooling is an excellent strategy for mitigating global warming, by enhancing heat fluxes away from the Earth, thus balancing the Earth's heat flow. However, for randomly particle-dispersed radiative cooling materials, the particle content as high as 94-96 wt % or 60 vol %, far exceeds the critical pigment percentage (40-50%) of traditional coatings, preventing its large-scale application. Here, inspired by particle deposition under gravity in solution, we demonstrate an auto-deposited SiO composite radiative cooling coating (ADRC) which reduces the amounts of particles required and lowers costs.
View Article and Find Full Text PDFInfluence of SS316L Nanoparticles on the Sintered Properties of Two-Component Micro-Powder Injection Moulded Bimodal SS316L/Zirconia Bi-Materials.
Materials (Basel)
November 2024
Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
Article Synopsis
- Two-component micro-powder injection moulding (2C-μPIM) is being explored as a cost-effective method to create bi-material micro-components using stainless steel 316L and zirconia, though it encounters challenges like cracks at material interfaces during sintering.
- This study focused on how incorporating SS316L nanoparticles into bimodal SS316L powders affects the sintering process and quality of the fabricated bi-materials.
- Results showed that increasing the nanoparticle content improved the critical powder loading, relative density, and hardness of the materials, with a notable reduction in interface cracks, achieving a completely crack-free interface at 45 vol.% nanoparticle content.
Enhanced extracellular production of Coprinopsis cinerea laccase Lcc9 in Aspergillus niger by gene expression cassette and bioprocess optimization.
BMC Biotechnol
November 2024
School of Life Sciences, Anhui University, Hefei, 230601, China.
Background: The laccase Lcc9 from Coprinopsis cinerea has optimal catalytic activity at moderate to alkaline pH conditions, making it invaluable for industrial applications. However, C. cinerea naturally secretes Lcc9 at low expression levels, which limits the industrial application of Lcc9 on a large scale.
View Article and Find Full Text PDFHigh-Throughput Multiplexed Plasmonic Color Encryption of Microgel Architectures via Programmable Dithering-Mask Flow Microlithography.
Adv Mater
November 2024
School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Article Synopsis
- * A new method using a digital micro-mirror device allows for high-throughput and cost-effective production of colored microparticles, increasing the encoding capacity of barcodes significantly.
- * This technique enables the creation of large-scale microgel arrays with multiple colors for secure data storage and anti-counterfeiting measures, and it can produce detailed images quickly, in under 30 minutes.
Examining ingested microplastics in fish: Considerations on filter pore size, analysis time, and material costs to design cost-effective projects.
Mar Environ Res
November 2024
Environment Climate Change Canada, Science and Technology Branch, Ottawa, ON, Canada, K1S 5B6. Electronic address:
In recent years the microplastics research community has called for methods harmonization and standardized metrics of reporting microplastic attributes. While alignment of research practices is essential in obtaining robust microplastic data, resource managers need to balance how the cost and effort of methodologies compare to data output. The intention of this study is to compare two recommended methods for isolating anthropogenic microparticles in fish gastrointestinal tracts.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!