AI Article Synopsis
- The study investigates the prognostic value of the pretreatment lymphocyte monocyte ratio (LMR) in patients with digestive system cancers, aiming to clarify its impact on survival outcomes.
- A meta-analysis of 22 cohort studies involving 12,829 patients reveals that lower LMR is linked to poorer overall survival, cancer-specific survival, and disease recurrence-free survival, with significant hazard ratios for all outcomes.
- The findings suggest that decreased LMR is a reliable indicator of worse prognosis across various types of digestive system tumors.
Article Abstract
Purpose. The prognostic value of pretreatment lymphocyte monocyte ratio (LMR) in digestive system cancer patients remains controversial. The aim of this study was to quantify the prognostic impact of this biomarker and assess its consistency in digestive system tumors. Methods. We searched "PubMed," "Embase," and "CBM" for published eligible studies before June 2016 and conducted a meta-analysis to estimate the pooled hazard ratios (HRs) for disease recurrence and mortality focusing on LMR. Subgroup analyses, meta-regression, and sensitivity analyses were also performed. Results. A total of 22 cohort studies enrolling 12829 patients with digestive system cancer were included. The summary results showed that lower LMR was significantly associated with worse overall survival (OS), cancer-specific survival (CSS), and tumor disease or recurrence-free survival (DFS/RFS) in analyses using the studies reporting HRs either by the univariate analyses (HR = 1.32, HR = 1.35, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.) or by multivariate analyses (HR = 1.21, HR = 1.18, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.). Conclusion. Our results support the fact that decreased LMR indicates worse prognosis in multiple digestive system tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993921 | PMC |
| http://dx.doi.org/10.1155/2016/9801063 | DOI Listing |
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