Purpose: Extracellular vesicle (EV) has been reported to conduct critical pathophysiological functions as an emerging mode of communication in bacteria. Recently, Propionibacterium acnes, an anaerobic Gram-positive human commensal found in the skin and gastrointestinal tract, has drawn increasing attention as an underestimated pathogen in a variety of diseases.
Experimental Design: For the comprehensive understanding of P. acnes, here we report the isolation of P. acnes EVs for the first time and identification of 252 vesicular proteins with high confidence using triplicate LC-MS/MS analyses.
Result: Comprehensive proteomic profiling reveals that P. acnes EVs harbor various proteins involved in biochemical processes, antibiotic resistance, bacterial competition, cell adherence, virulence, and immunogenicity.
Conclusion And Clinical Relevance: We believe that this report will provide valuable information for investigating the biological role of P. acnes EVs and effective targets for developing clinical applications against P. acnes.
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| http://dx.doi.org/10.1002/prca.201600040 | DOI Listing |
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Article Synopsis
- Cutibacterium acnes, a bacterium found on healthy skin, is linked to both acne vulgaris and has a potential protective role in atopic dermatitis (AD) by influencing immune response and skin health.* -
- The study analyzed extracellular vesicles (EVs) from C. acnes across AD lesions, acne lesions, and healthy skin, finding notable differences in protein expressions that correlate with the severity and type of skin condition.* -
- The results indicated that EVs from C. acnes exhibit different effects on inflammatory markers in skin cells, highlighting unique immunomodulatory functions in AD and acne, thus contributing to understanding skin health.*
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