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Imaging biomarker associated with early neurological deterioration in isolated pontine infarction.
Front Neurol
December 2024
Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Objective: To investigate the association between cerebral small vessel disease burden, along with its individual imaging features, as well as other imaging features and early neurological deterioration in isolated pontine infarction.
Methods: 107 patients with acute isolated pontine infarcts, within 24 h of symptom onset, were retrospectively analyzed. The mean age of the participants was 67 years.
Dorsolateral pontine lesions produce distinct ocular motor abnormalities with anatomical correlations.
Eur J Neurol
January 2025
Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Background And Purpose: The dorsolateral portion of the caudal pons contains the vestibular nucleus (VN) and inferior cerebellar peduncle (ICP) that play important roles in conveying and processing vestibular and ocular motor signals. This study aimed to characterize ocular motor abnormalities along with their anatomical correlations in dorsolateral pons (DLP) lesions.
Methods: We analyzed clinical features, and results of neuro-otological evaluations and neuroimaging of 18 patients with unilateral DLP lesions (17 with DLP infarction and 1 with cavernous malformation) from among 506 patients with pontine infarction in a stroke registry.
Cognitive Impairment and Brain Metabolic Changes in Post-Acute Sequelae of COVID-19: Insights From an [18F]FDG PET/CT Cohort Study.
Clin Nucl Med
December 2024
Hotel Dieu Hospital, Paris-Cité University, APHP, Department of Infectious Disease, Paris, France.
Purpose: Neurological symptoms often prominent in post-acute sequelae of COVID-19 (PASC) necessitate deeper understanding. Our objective was to investigate brain metabolism in PASC and examine correlations with neurological symptoms during both the acute and chronic stages.
Methods: Eighty-seven adults experiencing PASC with neurocognitive symptoms were recruited in the PERSICOR prospective study and examined using brain [18F]FDG PET/CT.
Aged mice show a reduction in 5-HT neurons and decreased cellular activation in the dentate gyrus when exposed to acute running.
Brain Struct Funct
December 2024
Laboratory of Molecular and Functional Neurobiology, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Serotonin (5-HT) is an important neurotransmitter for cognition and neurogenesis in the dentate gyrus (DG), which occurs via movement stimulation such as physical activity. Brain 5-HT function changes secondary to aging require further investigation. We evaluated whether aged animals would present changes in the number of 5-HT neurons in regions such as the dorsal (DRN) and median (MRN) raphe nuclei and possible changes in the rate of cellular activation in the DG in response to acute running, as a reduction in 5-HT neurons could contribute to a decline in neuronal activation in the DG in response to physical activity in aged mice.
View Article and Find Full Text PDFBasilar Dolichoarteriopathy and Early Clinical Deterioration in Acute Isolated Pontine Infarction.
Neurologist
December 2024
Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Article Synopsis
- Early clinical worsening (ECW) is common in patients with acute isolated pontine infarcts (AIPI) and may indicate a poor prognosis.
- A study of 146 AIPI patients explored the relationship between ECW and factors like the anatomy of the basilar artery, revealing that features such as female sex, longer branch length, and specific basilar artery height were significant predictors of ECW.
- In conclusion, characteristics of basilar dolichoarteriopathy could help identify AIPI patients at risk for ECW, emphasizing the importance of early assessment of these anatomical features.
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