Download full-text PDF |
Source |
---|
Nutrients
December 2024
Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
Background/objectives: Amyloid peptides, whose accumulation in the brain as senile plaques is associated with the onset of Alzheimer's disease, are also found in cerebral vessels and in circulation. In the bloodstream, amyloid peptides promote platelet adhesion, activation, oxidative stress, and thrombosis, contributing to the cardiovascular complications observed in Alzheimer's disease patients. Natural compounds, such as curcumin, are known to modulate platelet activation induced by the hemostatic stimuli thrombin and convulxin.
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Stroke remains a leading cause of global disability and mortality despite advancements in acute interventions. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has primarily been studied for its effects on cortical excitability, with limited exploration of its neuroprotective and hemodynamic benefits. This review examines the role of tDCS in stroke, with a focus on neuroprotection in acute settings and cerebral blood flow (CBF) modulation in both acute and chronic phases.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Emergency Medicine, Korea University Anam Hospital, Seoul 02841, Republic of Korea.
This study uses machine learning and multicenter registry data for analyzing the determinants of a favorable neurological outcome in patients with out-of-hospital cardiac arrest (OHCA) and developing decision support systems for various subgroups. The data came from the Korean Cardiac Arrest Research Consortium registry, with 2679 patients who underwent OHCA aged 18 or above with the return of spontaneous circulation (ROSC). The dependent variable was a favorable neurological outcome (Cerebral Performance Category score 1-2), and 68 independent variables were included, e.
View Article and Find Full Text PDFBrain Sci
December 2024
Clinic of Neurosurgery, Ankara Bilkent City Hospital, University of Health Science, Ankara 06290, Türkiye.
Background: In this study, we aimed to comparatively evaluate the morphology of internal carotid artery (ICA) bifurcations with and without aneurysms and identify risk factors for aneurysm development that are associated with the bifurcation geometry.
Method: In this two-center study, the computerized tomography angiography data of 1512 patients were evaluated. The study included 64 (4.
Biomolecules
December 2024
Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK 73117, USA.
Mild cognitive impairment (MCI) affects nearly 20% of older adults worldwide, with no targetable interventions for prevention. COVID-19 adversely affects cognition, with >70% of older adults with Long COVID presenting with cognitive complaints. Neurovascular coupling (NVC), an essential mechanism of cognitive function, declines with aging and is further attenuated in neurocognitive disorders.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!