A new approach to 19-nor-A-ring phosphine oxide 5 together with a convergent synthesis of the vitamin D analogue 1α,25-dihydroxy-19-norvitamin D (3) have been developed. The 19-nor-A-ring is constructed from (S)-carvone. The triene system is assembled by a Wittig-Horner coupling.
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| http://dx.doi.org/10.1016/j.jsbmb.2016.08.008 | DOI Listing |
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