AI Article Synopsis
- Fluoxetine is a medication used to treat Major Depressive Disorder and affects fear memory in mice.
- Chronic fluoxetine treatment impaired contextual fear memory in adult mice while leaving auditory fear memory unaffected.
- The treatment may selectively weaken the ability to form contextual fear memories, potentially serving as a therapeutic benefit.
Article Abstract
Fluoxetine is a medication used to treat Major Depressive Disorder and other psychiatric conditions. These experiments studied the effects of chronic fluoxetine treatment on the contextual versus auditory fear memory of mice. We found that chronic fluoxetine treatment of adult mice impaired their contextual fear memory, but spared auditory fear memory. Hippocampal perineuronal nets, which are involved in contextual fear memory plasticity, were unaltered by fluoxetine treatment. These data point to a selective inability to form contextual fear memory as a result of fluoxetine treatment, and they suggest that a blunting of hippocampal-mediated aversive memory may be a therapeutic action for this medication.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042869 | PMC |
| http://dx.doi.org/10.1016/j.neulet.2016.08.057 | DOI Listing |
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