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| http://dx.doi.org/10.1074/jbc.A115.707752 | DOI Listing |
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FgGET3, an ATPase of the GET Pathway, Is Important for the Development and Virulence of .
Int J Mol Sci
November 2024
Triticeae Research Institute, Sichuan Agricultural University, Chengdu 611130, China.
GET3 is an ATPase protein that plays a pivotal role in the guided entry of the tail-anchored (GET) pathway. The protein facilitates the targeting and inserting of tail-anchored (TA) proteins into the endoplasmic reticulum (ER) by interacting with a receptor protein complex on the ER. The role of GET3 in various biological processes has been established in yeast, plants, and mammals but not in filamentous fungi.
View Article and Find Full Text PDFAnalysis of protein trafficking between mitochondria and the endoplasmic reticulum by fluorescence microscopy.
Methods Enzymol
November 2024
Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan; Institute for Protein Dynamics, Kyoto Sangyo University, Kyoto, Japan. Electronic address:
Precise protein localization is essential for normal cellular functions. However, recent studies have revealed that protein targeting is error-prone, and tail-anchored proteins mistargeted to mitochondria are transferred to the endoplasmic reticulum (ER) by an ATPase Msp1 (yeast)/ATAD1 (human) in the mitochondrial outer membrane for further quality examination in the ER to determine their fate, degradation or re-targeting. Analysis of the inter-organelle transfer of proteins requires a combination of time-lapse fluorescence microscopy and a system to achieve regulation of the protein levels of both transfer substrates and factors regulating the transfer in a coordinated manner at precise timing.
View Article and Find Full Text PDFMembrane Interactions of GET1 and GET2 Facilitate Fiber Cell Initiation through the Guided Entry of the TA Protein Pathway in Cotton.
J Agric Food Chem
November 2024
Zhengzhou Research Base, State Key Laboratory of Cotton Bio-breeding and Integrated Utilization, Zhengzhou University, Zhengzhou 450001, China.
The guided entry of TA proteins (GET) pathway, which is responsible for the post-translational targeting and insertion of the tail-anchored (TA) protein into the endoplasmic reticulum (ER), plays an important role in physiological processes such as protein sorting, vesicle trafficking, cell apoptosis, and enzymatic reactions in which the GET1/2 complex is indispensable. However, a comprehensive study of the and genes and the GET pathway in cotton has not yet been carried out. Here, 12 and 21 genes were identified in nine representative plant species, and the phylogenetic relationships, gene structures, protein motifs, cis-regulatory elements (CREs), and temporal and spatial expression profiles were analyzed thoroughly.
View Article and Find Full Text PDFRibosome-inactivation by a class of widely distributed C-tail anchored membrane proteins.
Structure
December 2024
Institut für Biochemie und Molekularbiologie, ZBMZ, Faculty of Medicine, Albert-Ludwigs-Universität Freiburg, 79104 Freiburg, Germany. Electronic address:
Ribosome hibernation is a commonly used strategy that protects ribosomes under unfavorable conditions and regulates developmental processes. Multiple ribosome-hibernation factors have been identified in all domains of life, but due to their structural diversity and the lack of a common inactivation mechanism, it is currently unknown how many different hibernation factors exist. Here, we show that the YqjD/ElaB/YgaM paralogs, initially discovered as membrane-bound ribosome binding proteins in E.
View Article and Find Full Text PDFTail-anchored membrane protein SLMAP3 is essential for targeting centrosomal proteins to the nuclear envelope in skeletal myogenesis.
Open Biol
October 2024
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada K1H 8M5.
Article Synopsis
- In cell division and muscle growth, the nucleus and centrosomes need to work together properly.
- Scientists found that a protein called SLMAP3 helps place nuclei correctly during muscle development, and without it, muscles don’t form properly in mice.
- SLMAP3 is important for organizing the cell parts and making sure muscle cells grow and develop in the right way.
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