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Detection of circulating vaccine-derived poliovirus type 2 (cVDPV2) in wastewater samples: a wake-up call, Finland, Germany, Poland, Spain, the United Kingdom, 2024.
Euro Surveill
January 2025
Medicines and Healthcare products Regulatory Agency (MHRA), South Mimms (Potters Bar), United Kingdom.
In 2024, circulating vaccine-derived poliovirus type 2 (cVDPV2) was detected in wastewater samples in Finland, Germany, Poland, Spain and the United Kingdom (UK). All strains were genetically linked, but sequence analysis showed high genetic diversity among the strains identified within individual wastewater sites and countries and an unexpected high genetic proximity among isolates from different countries. Taken together these results, with sequential samples having tested positive in various sites, a broader geographic distribution beyond positive sampling sites must be considered.
View Article and Find Full Text PDFVaccine-derived poliovirus type 3 emergence in Guinea, 2024.
Lancet Infect Dis
January 2025
WHO, Conakry, Guinea.
Community acceptance of services and effectiveness of health camps in high-risk areas of Karachi, Sindh, Pakistan, 2021.
Front Public Health
January 2025
Provincial Emergency Operation Center (PEOC), Government of Sindh, Karachi, Pakistan.
Introduction: Health camps are organized to provide basic health services in underprivileged communities. This study was conducted to determine community acceptance and effectiveness of health camps in the high-risk areas for the polio program in Karachi, Pakistan.
Methods: This cross-sectional survey was conducted at the health campsites in high-risk union councils (HRUCs) of four districts of Karachi, Sindh.
Polio Eradication in Pakistan: Innovation and Digitalization-the Key to Crossing the Finish Line.
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Primary and Secondary Healthcare Department, Punjab, Lahore, Pakistan.
Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.
Nat Commun
January 2025
Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Polioviruses have caused crippling disease in humans for centuries, prior to the successful development of vaccines in the mid-1900's, which dramatically reduced disease prevalence. Continued use of these vaccines, however, threatens ultimate disease eradication and achievement of a polio-free world. Virus-like particles (VLPs) that lack a viral genome represent a safer potential vaccine, although they require particle stabilization.
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