AI Article Synopsis
- Naïve CD4+ T cells can become different types of T cells based on the surrounding cytokines, with TH9 cells being less understood compared to others.
- Recent research has identified key factors that regulate the development and function of TH9 cells, highlighting their importance in various immune-mediated diseases.
- Targeting TH9 cell differentiation and activity could lead to new treatment strategies for conditions like allergies, autoimmune diseases, inflammatory bowel diseases, and cancer.
Article Abstract
Naïve CD4+T cells differentiate into various T cell subsets depending on the specific cytokine environment. TH9 cells are less well-characterized than other T cell subsets, and factors that control their development and function have only recently been identified. It is now clear that TH9 cells play critical roles in immune-mediated diseases, including allergic airway, autoimmune and inflammatory bowel diseases, and cancer. Thus, the promotion or suppression of TH9 cell differentiation, transcriptional control and function may provide novel treatments for clinical inflammation, autoimmune diseases and tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342605 | PMC |
| http://dx.doi.org/10.18632/oncotarget.11681 | DOI Listing |
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Article Synopsis
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