AI Article Synopsis
- Carbapenem-Resistant Enterobacteriaceae (CRE) infections are a significant healthcare threat, leading to high rates of illness and death, especially in critically ill patients.
- Limited treatment options exist due to their multi-drug resistant nature, with potential therapies including carbapenems, polymyxins, and others.
- The review emphasizes the importance of understanding pharmacokinetics and pharmacodynamics (PK-PD) to enhance the effectiveness of these treatment options for CRE infections.
Article Abstract
Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that have been described for the treatment of CRE infections include carbapenems, polymyxins, fosfomycin, tigecycline, aminoglycosides, and ceftazidime-avibactam. Given the limited treatment options it is imperative the pharmacokinetic and pharmacodynamics (PK-PD) characteristics of these agents are considered to optimize treatment regimens. This review will focus on the PK-PD challenges of the current treatment options for CRE infections.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477717 | PMC |
| http://dx.doi.org/10.1080/21505594.2016.1221021 | DOI Listing |
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