AI Article Synopsis
- Plant-based natural products, especially cassane-type diterpenes from the genus Caesalpinia, are valuable sources for new cancer treatments.
- A study found that among 16 isolated compounds, caesalpin G (CAG) exhibited the strongest anticancer effects on pituitary adenoma cells.
- The research identified key structural features essential for anticancer activity and indicated that CAG triggers cell death through mechanisms involving protein stress responses and the Wnt/β-catenin signaling pathway.
Article Abstract
Plant-derived natural products have been the highly significant sources of novel antitumor agents. The cassane-type diterpenes of genus Caesalpinia have been reported to bear antiproliferative activities toward different types of cancer cells. In this study, we evaluated the antineoplasmic activities of 16 natural origin cassane-type diterpenes isolated from the CHCl extract of the seeds of C. minax in pituitary adenomas cells and identified caesalpin G (CAG) showed the strongest cytotoxicity. Moreover, we further investigated the structure-activity relationship and molecular mechanism of these derivatives systematically. The results confirmed the unsaturated lactone-type ring, hydroxyl at C-7, and alkenyl at C-11 or C-14 functionality as critical for anticancer activity in this family of natural products. In addition, the mechanism experiments also demonstrated unfolded protein response and ER stress and Wnt/β-catenin pathway were involved in the CAG-induced apoptosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10286020.2016.1217520 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!