AI Article Synopsis
- - Paget's disease is a bone metabolic disorder characterized by abnormal remodeling, more prevalent in Western countries compared to rare cases in Asians and Africans, and was first identified by Sir James Paget in 1877.
- - The condition can involve either one bone (monostotic) or multiple bones (polyostotic) and typically affects individuals over 50 years old.
- - Diagnosis involves elevated serum alkaline phosphatase levels, imaging tests such as X-rays, and radioisotope bone scans to assess the extent of the disease.
Article Abstract
Paget's disease is a metabolic disorder of bone caused due to defect in the remodelling process and is very common in western countries but is very rare in Asians and Africans. It was first described by a British scientist Sir James Paget in 1877. It can be monostotic or polyostotic depending on the number of bones involved. It most commonly affects older people of more than 50 years. Disease involvement can be symptomatic or asymptomatic depending on the extent of the disease process. Diagnosis of Paget's disease can be made by raised serum alkaline phosphatase levels, radiological examination and by radioisotope bone scans.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020724 | PMC |
| http://dx.doi.org/10.1136/bcr-2016-216173 | DOI Listing |
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