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Immune-related adverse events associated with mogamulizumab: a comprehensive review of the literature.
Expert Rev Anticancer Ther
September 2024
Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA.
Introduction: Mogamulizumab is an anti-C-C chemokine receptor 4 antibody that is increasingly being used to treat T-cell malignancies such as cutaneous T-cell lymphoma, adult T-cell leukemia-lymphoma, and peripheral T-cell lymphoma. Because CCR4 is expressed on both malignant T-cells and regulatory T-cells (Tregs), mogamulizumab can be associated with increased immune-related adverse events (irAEs). While there is abundant literature on mogamulizumab-associated rash (MAR) and graft-versus-host disease (GVHD), other reported irAEs have not been collated into a single review.
View Article and Find Full Text PDFJanus-kinase inhibitors in dermatology: A review of their use in psoriasis, vitiligo, systemic lupus erythematosus, hidradenitis suppurativa, dermatomyositis, lichen planus, lichen planopilaris, sarcoidosis and graft-versus-host disease.
Indian J Dermatol Venereol Leprol
January 2024
Keck School of Medicine, University of Southern California, Los Angeles, United States.
Recent studies on molecular pathways have elucidated novel therapeutic approaches in inflammatory and autoimmune skin disorders. Specifically, the dysregulation of the Janus kinase signal transducer and activator of transcription (JAK-STAT) cascade plays a central role in the pathogenesis of many skin conditions. JAK inhibitors, with their ability to selectively target immune responses, are potential treatment options.
View Article and Find Full Text PDFRisk of autoimmune skin and connective tissue disorders after mRNA-based COVID-19 vaccination.
J Am Acad Dermatol
October 2023
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:
Background: Data on the association between the development of autoimmune diseases and COVID-19 vaccination are limited.
Objective: To investigate the incidence and risk of autoimmune connective tissue disorders following mRNA-based COVID-19 vaccination.
Methods: This nationwide population-based study was conducted in South Korea.
Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort.
Front Neurol
November 2021
Department of Neurology, Huashan Hospital Fudan University, Shanghai, China.
The phenomenon of coexisting autoimmune diseases (ADs) in patients with myasthenia gravis (MG) has attracted considerable attention. However, few studies have investigated the burden and potential clinical associations of ADs in Chinese MG cohorts. In this retrospective cross-sectional study, we reviewed the records of 1,132 patients with MG who were admitted to Huashan Hospital Fudan University from August 2013 to August 2020.
View Article and Find Full Text PDFRisk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study.
Arthritis Res Ther
August 2019
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Objective: To investigate the risk of immune-mediated inflammatory diseases (IMIDs) in patients with ankylosing spondylitis (AS).
Methods: Using 2003-2012 claims data from the Taiwanese National Health Insurance Research Database, we identified 30,911 newly diagnosed AS patients requiring medical therapy from 2006 to 2012. In addition, we randomly selected 309,110 non-AS individuals matching (1:10) the AS patients with regard to age, sex and the year of the index date.
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