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Filename: controllers/Detail.php
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Purpose: The Notch signaling pathway is widely expressed in normal, reactive, and neoplastic tissues; however, its role in thyroid tissues has not been fully elucidated. Therefore, this study was conducted to characterize the expression of the Notch signaling pathway in papillary thyroid cancer (PTC) cells and anaplastic thyroid cancer (ATC) cells.
Materials And Methods: Expression of activated Notch1 in ATC and PTC paraffin-embedded tissues was determined by immunohistochemistry. The small interfering RNA techniquewas employed to knock down Notch1 expression in ATC and PTC cell lines.
Results: The expression of activated Notch1 was higher in ATC cases than in PTC cases. Inhibition of Notch1 significantly reduced proliferation and migration of ATC cells, but not PTC cells. In addition, inhibition of Notch1 in ATC cells significantly reduced the expression of key markers of epithelial-mesenchymal transition and cancer stem cells. Conversely, changes in the expression of these proteins were not observed in PTC cells.
Conclusion: The results of this study suggest that Notch1 expression plays different roles in tumor progression in ATC and PTC cells. We also found that Notch1 expression was significantly related to the highly invasive or proliferative activity of ATC cells.
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http://dx.doi.org/10.4143/crt.2016.214 | DOI Listing |
Small
December 2024
School of Materials Science and Engineering, State Key Laboratory of Material Processing and Die and Mold Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.
The oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are key processes in numerous oxygen-involved applications over a wide temperature range. Despite advances in nanofiber engineering to increase active site density and catalytic efficiency for ORR/OER, conventional electrode fabrication methods often compromise the integrity of nanofibrous structures. Herein, a robust strategy is presented for the fabrication of LaCoNiO (LCN) nanofibrous membranes using optimized electrospinning techniques.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
Division of Endocrinology, Mayo Clinic, Jacksonville, FL, United States.
Introduction: BRAFV600E mutation (BRAF) is common in papillary thyroid cancer (PTC), and most patients have an excellent outcome. However, a TERT-promoter mutation (pTERT) in the presence of BRAF (BRAFpTERT) has been demonstrated to confer a more aggressive behavior to PTC. Lymphocytic infiltration is often present in PTC.
View Article and Find Full Text PDFChempluschem
December 2024
Qinghai University, Mechanical Engineering, Qinghai,China, 810016, Qinghai province, CHINA.
Due to the high catalytic activity and stability for oxygen reduction reaction, N-coordinated Fe-Cu dual-metal doped carbon material (FeCu-N-C) is considered to be one of the promising electrode materials for metal-air battery and fuel cells. Herein, FeCu-N-C dual-metal catalysts was synthesized by an adsorption-calcination strategy. The prepared FeCu-N-C exhibited high activity and stability both in alkaline and acidic media.
View Article and Find Full Text PDFMol Genet Genomics
December 2024
Histopathology Laboratory, Kuwait Cancer Control Center (KCCC), Sabah Health Area, Ministry of Health, Shuwaikh, State of Kuwait.
Objective: . Despite the establishment of a link between telomere status and carcinogenesis, lack of a consensus in the cancer specific pattern of telomere length has a severe impact on the use of relative telomere length (RTL) in cancer diagnosis. The disparity in assessing the relationship between telomere length and cancer risk is complex and may vary as it is influenced by other factors.
View Article and Find Full Text PDFFASEB J
December 2024
State Key Laboratory of Microbial Technology, Shandong University-Qingdao Campus, Qingdao, P.R. China.
Mammalian spermatogenesis is a tightly controlled cellular process including spermatogonial development and differentiation, meiosis of spermatocyte, and the morphological specification of haploid spermatozoa, during which the post-transcriptional gene regulations are vital but poorly understood. Nonsense-mediated mRNA decay (NMD), a highly conserved post-transcriptional regulatory mechanism of gene expression in eukaryotes, recently emerges as a licensing mechanism in cell fate transition, including stem cell differentiation and organogenesis. The function of NMD in spermatogonial development remains elusive.
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