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Dealing with the Verteporfin Shortage: Treatment Options and Outcomes in Patients with Chronic and Non-Resolving Central Serous Chorioretinopathy.
Ophthalmologica
October 2024
Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.
Introduction: Half-dose photodynamic therapy (HD-PDT) with verteporfin is the mainstay treatment in central serous chorioretinopathy (CSC). Since 2021, there is a worldwide shortage of verteporfin. This called for adjustments of daily practice.
View Article and Find Full Text PDFNovel Aptamer Strategies in Combating Bacterial Infections: From Diagnostics to Therapeutics.
Pharmaceutics
August 2024
Department of Orthopedics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Article Synopsis
- Bacterial infections and antimicrobial resistance are major challenges for global healthcare, revealing limitations in traditional diagnostic and treatment methods and emphasizing the need for new approaches.
- Aptamers are synthetic oligonucleotides that show promise in managing bacterial infections by providing high specificity and effectiveness in both diagnosis and therapy, including early detection and suppressing bacterial growth.
- The review highlights how aptamers can also improve immune responses and serve in advanced treatment methods while discussing potential challenges like stability and degradation, aiming to expand their clinical applications.
Potential of Resveratrol to Combine with Hydrogel for Photodynamic Therapy against Bacteria and Cancer-A Review.
Biomedicines
September 2024
Department of Food and Health Sciences, The Technological and Higher Education Institute of Hong Kong, Tsing Yi, New Territories, Hong Kong, China.
Unlabelled: Bacterial infections and cancers are important issues in public health around the world. Currently, Western medicine is the most suitable approach when dealing with these issues. "Antibiotics" and "Corticosteroids" are the Western medicines used for bacterial infection.
View Article and Find Full Text PDFProspects, advances and biological applications of MOF-based platform for the treatment of lung cancer.
Biomater Sci
July 2024
Dongguan Key Laboratory of Drug Design and Formulation Technology, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, 523808, China.
Nowadays in our society, lung cancer is exhibiting a high mortality rate and threat to human health. Conventional diagnostic techniques used in the field of lung cancer often necessitate the use of extensive instrumentation, exhibit a tendency for false positives, and are not suitable for widespread early screening purposes. Conventional approaches to treat lung cancer primarily involve surgery, chemotherapy, and radiotherapy.
View Article and Find Full Text PDFCurrent and novel therapies for management of -associated pneumonia.
Crit Rev Microbiol
July 2024
Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Article Synopsis
- A common pathogen linked to hospital-acquired pneumonia shows increasing resistance to key antibiotics, highlighting the need for new treatment options.
- The review examines both current and innovative therapeutic strategies, including antibiotic combination therapies which have yielded mixed results in studies.
- It also discusses emerging therapies like antimicrobial peptides, bacteriophage-based treatments, and nanoparticle therapies, emphasizing the need for further research to ensure their safety and effectiveness before being used clinically.
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