In paediatric patients positive end-expiratory pressure (PEEP) is traditionally set lower than in adults. We investigated whether moderately higher PEEP improves respiratory mechanics and regional ventilation. Therefore, 40 children were mechanically ventilated with PEEP 2 and 5cmHO. Volume-dependent compliance profiles were analysed as a measure of intratidal recruitment/derecruitment. Regional ventilation was assessed using electrical impedance tomography. Mean compliance was 17.9±9.9mLcmHO (PEEP 2cmHO), and 19.0±10.9mLcmHO (PEEP 5 cmHO, p<0.001). Strong intratidal recruitment/derecruitment occurred in 40% of children at PEEP 2 cmHO, and 36% at PEEP 5 cmHO. Children showing strong recruitment/derecruitment were 33 (PEEP 2 cmH0) and 20 (PEEP 5 cmH0) months younger than children showing moderate recruitment/derecruitment. A higher PEEP improved peripheral ventilation. In conclusion, mechanically ventilated paediatric patients undergo intratidal recruitment/derecruitment which occurs more prominently in younger than in older children. A PEEP of 5cmHO does not fully prevent intratidal recruitment/derecruitment but homogenizes regional ventilation in comparison to 2cmHO.
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