AI Article Synopsis
- Competitive quorum sensing (QS) antagonism is a potential strategy to combat multidrug-resistant staphylococcal infections.
- Researchers tested 10 truncated analogues of autoinducing peptides (AIPs) from Staphylococcus lugdunensis and Staphylococcus epidermidis, finding varying degrees of effectiveness.
- The most promising analogues showed low IC values, indicating their potential for inhibiting QS and reducing infections from species beyond just Staphylococcus aureus.
Article Abstract
Competitive quorum sensing (QS) antagonism offers a novel strategy for attenuating current multidrug resistant staphylococcal infections. To this end, a series of 10 truncated analogues based on the parent autoinducing peptides (AIPs) of Staphylococcus lugdunensis (groups I and II) and Staphylococcus epidermidis (groups I-III) were sequentially assessed against a newly developed Staphylococcus lugdunensis group I QS reporter strain. The truncated analogues based upon Staphylococcus lugdunensis AIP-1 (1) and AIP-2 (2) displayed respective IC values of 0.2 ± 0.01 μM and 0.3 ± 0.01 μM, while the truncated analogue of the Staphylococcus epidermidis AIP-1 (3) elicited an IC value of 2.7 ± 0.1 μM. These findings demonstrate the potential of cognate and "crosstalk" competitive quorum sensing inhibition using truncated AIPs as a means of attenuating staphylococcal infections in species beyond Staphylococcus aureus.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234682 | PMC |
| http://dx.doi.org/10.1021/acs.jmedchem.6b00727 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!