The study examined the relationship between class I HLA antigens and type II diabetes with regard to insulin secretion and hyperlipoproteinemia. Out of 28 HLA antigens of A, B and C loci, 46 type II diabetics had statistically more significant HLA Cw1 - 15.9% as compared with 6.3% of the control group, the relative risk being 2.81. These patients were younger than the other diabetics but showed no difference in insulin secretion or hyperlipoproteinemia. Diabetics with HLA Cw4, just as patients after myocardial infarction with concomitant hyperlipoproteinemia, were also found frequently to have hyperlipoproteinemia (89 percentage cases as compared to 63% of the other diabetics). The findings may be indicative of potential genetic heterogeneity of type II diabetes. The paper stresses the necessity of establishing suitable genetic characters for early diagnosis of diabetes and its development.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
CD3/CD20/CD45 negative leukemia cutis.
J Hematop
January 2025
Cleveland Clinic Florida, Weston, USA.
A 56-year-old male presented to the clinic with complaints of multiple skin lesions. A complete blood count (CBC) was not available. No constitutional symptoms were present, and physical examination revealed tender skin lesions of the back, arms, legs, and scalp.
View Article and Find Full Text PDFPeriductal fibroblasts participate in liver homeostasis, fibrosis, and tumorigenesis.
J Exp Med
April 2025
Key Laboratory of Multi-Cell System, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Hepatic fibroblasts comprise groups of stromal cells in the liver that are phenotypically distinct from hepatic stellate cells. However, their physiology is poorly understood. By single-cell RNA sequencing, we identified Cd34 and Dpt as hepatic fibroblast-specific genes.
View Article and Find Full Text PDFLipid Profile, PCSK9, ANGPTL3 and Lipoprotein (a) Levels in Men Diagnosed With Localized High-Grade Prostate Cancer and Men At-Risk of Prostate Cancer.
Cancer Med
February 2025
Oncology Research Axis, Centre de Recherche du CHU de Québec-Université Laval, Quebec City, Quebec, Canada.
Background: Some cancers have been found to require abundant supplies of lipids for their development. One example is prostate cancer (PCa). To date, lipid-modifying factors, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), angiopoietin-like 3 protein (ANGPTL3), and lipoprotein(a) or Lp(a), have not been reported in men with PCa.
View Article and Find Full Text PDFVirus-host immune interaction in asymptomatic HTLV-1 carriers.
Microbiol Spectr
January 2025
Graduate School of Medical Sciences and Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Unlabelled: Human T-cell leukemia virus type 1 (HTLV-1) induces chronic long-term latent infection that can cause fatal diseases, including adult T-cell leukemia. HTLV-1 production is poor and undetectable during the asymptomatic phase of infection. Virus-host immune interaction in latent infection has not been fully determined.
View Article and Find Full Text PDFsp. nov., sp. nov. and sp. nov. isolated from a cave, and an emended description of the genus .
Int J Syst Evol Microbiol
January 2025
Department of Biological Sciences and Biotechnology, Hannam University, Daejeon 34054, Republic of Korea.
Six Gram-reaction-positive, strictly aerobic, mycelium-forming actinobacteria were isolated from soils collected from a natural cave in Jeju, Republic of Korea. The isolates produced well-developed, branched, substrate mycelia and white aerial mycelia that differentiated into straight or flexuous chains of smooth-surfaced spores. Cells showed growth at 15-30 °C, pH 3.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!