[This corrects the article DOI: 10.1371/journal.pone.0159959.].
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Neural Comput
January 2025
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200437, China
Spiking neural networks (SNNs) have attracted significant interest in the development of brain-inspired computing systems due to their energy efficiency and similarities to biological information processing. In contrast to continuous-valued artificial neural networks, which produce results in a single step, SNNs require multiple steps during inference to achieve a desired accuracy level, resulting in a burden in real-time response and energy efficiency. Inspired by the tradeoff between speed and accuracy in human and animal decision-making processes, which exhibit correlations among reaction times, task complexity, and decision confidence, an inquiry emerges regarding how an SNN model can benefit by implementing these attributes.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute for Experimental Immunology, affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Schleswig-Holstein, Germany.
Background: In 2023, the FDA approved LEQEMBI, a monoclonal antibody therapy targeting beta-amyloid plaques, for patients with early-stage Alzheimer's disease (AD). However, anti-amyloid drug trials demonstrated an elevated risk for amyloid-related imaging abnormalities with cerebral edema (ARIA-E) in carriers of the AD risk allele apolipoprotein E epsilon 4 (APOE-ɛ4), especially in ɛ4/ɛ4 homozygous individuals. Here, we report on the evaluation of a new real-time polymerase chain reaction (PCR) test for APOE genotyping.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
January 2025
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, Jiangsu, PR China. Electronic address:
Metal aluminum ions and the antibiotic NOR have both benefited humanity and due to improper use, posed significant threats to the environment and human health. Although the correct and rational use of these substances is crucial, developing real-time, rapid, and highly sensitive detection of trace aluminum ions and NOR in the environment and organisms is more important for early diagnosis of potential related diseases. After several decades of development, fluorescence analysis has become a mainstream research method due to its ability to meet these requirements.
View Article and Find Full Text PDFBioinformatics
January 2025
Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina, USA.
Motivation: As nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long reads, real-time signal analysis, and the ability to read both DNA and RNA. We need flexible and efficient designs that match nanopore's capabilities, but relatively few designs have been explored and many have significant inefficiency in read density, error rate, or compute time.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
January 2025
NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Kent Ridge, 117456, Singapore.
Detecting alterations in plasmid structures is often performed using conventional molecular biology. However, these methods are laborious and time-consuming for studying the conditions inducing these mutations, which prevent real-time access to cell heterogeneity during bioproduction. In this work, we propose combining both flow cytometry and fluorescence-activated cell sorting, integrated with mechanistic modelling to study conditions that lead to plasmid recombination using a limonene-producing microbial system as a case study.
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