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| http://dx.doi.org/10.21037/sci.2016.07.05 | DOI Listing |
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BMI1 governs the maintenance of mouse GC-2 cells through epigenetic repression of transcription.
Am J Transl Res
May 2022
State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Objectives: Studies have demonstrated that B lymphoma Mo-MLV insertion region 1 (BMI1) plays an important role in male reproductive function and the regulation of spermatogonia proliferation. However, whether BMI1 exerts a similarly important function in spermatocyte development remains unclear.
Methods: In this study, we investigated the role of BMI1 in spermatocyte development using a mouse spermatocyte-derived cell line (GC-2) and a -knockout (KO) mouse model.
BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b/β-catenin signaling.
Int J Biol Sci
May 2022
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226001, China.
The self-renewal of spermatogonial stem cells (SSCs) requires a special microenvironment and is strictly controlled. Previously, we identified BMI1 as a key regulator of spermatogenesis in a knock-out mouse model. However, the mechanisms by which BMI1 regulates SSC maintenance remain largely unknown.
View Article and Find Full Text PDFBMI1 promotes spermatogonia proliferation through epigenetic repression of Ptprm.
Biochem Biophys Res Commun
November 2021
State Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, China. Electronic address:
Spermatogonia are accountable for spermatogenesis and male fertility, but the underlying mechanisms involved in spermatogonia maintenance are not clear. B lymphoma Mo-MLV insertion region 1 (BMI1) is a key component of epigenetic silencers. BMI1 is essential for stem-cell maintenance.
View Article and Find Full Text PDFBMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway.
Front Cell Dev Biol
April 2021
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, China.
Testosterone biosynthesis progressively decreases in aging males primarily as a result of functional changes to Leydig cells. Despite this, the mechanisms underlying steroidogenesis remain largely unclear. Using gene knock-out approaches, we and others have recently identified as an anti-aging gene.
View Article and Find Full Text PDFEZH2 facilitates BMI1-dependent hepatocarcinogenesis through epigenetically silencing microRNA-200c.
Oncogenesis
November 2020
Department of Biliary-Pancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
EZH2, a histone methyltransferase, has been shown to involve in cancer development and progression via epigenetic regulation of tumor suppressor microRNAs, whereas BMI1, a driver of hepatocellular carcinoma (HCC), is a downstream target of these microRNAs. However, it remains unclear whether EZH2 can epigenetically regulate microRNA expression to modulate BMI1-dependent hepatocarcinogenesis. Here, we established that high EZH2 expression correlated with enhanced tumor size, elevated metastasis, increased relapse, and poor prognosis in HCC patients.
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