AI Article Synopsis
- The study examined how alpha-interferon (Roferon-A) impacts the pharmacokinetics and metabolism of theophylline in healthy adults, involving daily intramuscular injections and aminophylline infusions.
- Blood and urine samples were collected to analyze theophylline and its metabolites, leading to calculations on various pharmacokinetic parameters.
- Results showed that alpha-interferon increased the elimination half-life and decreased plasma clearance of theophylline, indicating a significant interaction, but further research is needed to understand the duration of treatment's effects.
Article Abstract
1. The influence of alpha-interferon (Roferon-A) on the pharmacokinetics and metabolism of theophylline was studied in healthy adults. Roferon-A was administered as an intra-muscular injection (3 x 10(6) iu) once-a-day over 3 days. One week prior to and immediately after this course a single 20 min aminophylline infusion (4 mg kg-1) was given. 2. Blood samples for theophylline analysis were taken over 48 h. Urine was collected up to 72 h and assayed for theophylline and its major metabolites 3-methylxanthine, 1,3-dimethyluric acid and 1-methyluric acid. 3. Pharmacokinetic parameters for theophylline in plasma were calculated. From urinary excretion data the overall metabolic clearance of theophylline and clearances for formation of the metabolites were calculated. 4. After interferon administration, there was a significant increase of approximately 15% in the mean values of the terminal elimination half-life, area under the curve and mean residence time of theophylline in association with a similar decrease in plasma clearance (P less than 0.05). Formation clearances of the metabolites tended to be smaller after treatment, but only the change in the overall clearance of theophylline was significantly different (P less than 0.05). There was no systematic shift in the metabolic pattern of theophylline. 5. Additional investigations of the influence of the duration of alpha-interferon treatment are necessary before definite conclusions can be drawn about the mechanism and the clinical relevance of the described interaction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1379807 | PMC |
| http://dx.doi.org/10.1111/j.1365-2125.1989.tb03442.x | DOI Listing |
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